The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
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INVESTIGACIONMetadades
Títol
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteriaAutoria
Data de publicació
2022Editor
Nature ResearchISSN
2399-3642Cita bibliogràfica
González-Magaña, A., Altuna, J., Queralt-Martín, M. et al. The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria. Commun Biol 5, 1189 (2022). https://doi.org/10.1038/s42003-022-04140-yTipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.nature.com/articles/s42003-022-04140-yVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen ... [+]
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to persist and prevail during the onset of infections. However, despite the high clinical relevance of P. aeruginosa, the identity and mode of action of most P. aeruginosa T6SS-dependent effectors remain to be discovered. Here, we report the molecular mechanism of Tse5-CT, the toxic auto-proteolytic product of the P. aeruginosa T6SS exported effector Tse5. Our results demonstrate that Tse5-CT is a pore-forming toxin that can transport ions across the membrane, causing membrane depolarisation and bacterial death. The membrane potential regulates a wide range of essential cellular functions; therefore, membrane depolarisation is an efficient strategy to compete with other microorganisms in polymicrobial environments. [-]
Publicat a
Communications Biology, 2022, vol. 5, no 1Entitat finançadora
Ministerio de Economía y Competitividad (España) | Ministerio de Ciencia e Innovación | Gobierno Vasco | Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana | Universitat Jaume I
Identificador de l'entitat finançadora
http://dx.doi.org/10.13039/501100003329 | http://dx.doi.org/10.13039/501100004837 | http://dx.doi.org/10.13039/501100011033
Codi del projecte o subvenció
MINECO/CTQ2016-76941-R | MICINN/PID2021-127816NB-I00 | IT709-13 | IT1745-22 | MICIU/ICTI2017-2020/PID2021-127816NB-I00 | AICO/2020/066 | UJI-B2018-53 | MICIU/IJC2018-035283-I | UJI-A2020–21 | MICINN/RYC2019-026551-I
Títol del projecte o subvenció
Estudio biofísico de los mecanismos de permeabilización de membranas inducidos por canales iónicos
Drets d'accés
info:eu-repo/semantics/openAccess
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