Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population
Impacte
Scholar |
Altres documents de l'autoria: Barragán-Arnal, Rocío; Sánchez González, Cristina; Aranda, Pilar; Sorlí, José V; Asensio, Eva Maria; Portolés, Olga; Ortega-Azorín, Carolina; Villamil, Laura V.; Coltell, Oscar; Llopis, Juan; Rivas García, Lorenzo; Corella, Dolores
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7038
comunitat-uji-handle3:10234/8634
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean PopulationAutoria
Data de publicació
2022-10ISSN
2076-3921Cita bibliogràfica
Barragán, R.; Sánchez-González, C.; Aranda, P.; Sorlí, J.V.; Asensio, E.M.; Portolés, O.; Ortega-Azorín, C.; Villamil, L.V.; Coltell, O.; Llopis, J.; Rivas-García, L.; Corella, D. Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population. Antioxidants 2022, 11, 1991. https://doi.org/10.3390/antiox11101991Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.mdpi.com/2076-3921/11/10/1991Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse ... [+]
Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse associations between some of the most important essential trace elements (Zn, Cu, Se, and Mn) and cardiovascular disease, several recent studies have reported a direct association with cardiovascular risk factors due to the fact that these elements can act as both antioxidants and pro-oxidants, depending on several factors. This study aims to investigate the association between plasma and urine concentrations of trace elements and cardiovascular risk factors in a general population from the Mediterranean region, including 484 men and women aged 18–80 years and considering trace elements individually and as joint exposure. Zn, Cu, Se, and Mn were determined in plasma and urine using an inductively coupled plasma mass spectrometer (ICP-MS). Single and combined analysis of trace elements with plasma lipid, blood pressure, diabetes, and anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, and calculation of trace element risk scores (TERS) were used for the combined analyses. Models were adjusted for covariates. In single trace element models, we found statistically significant associations between plasma Se and increased total cholesterol and systolic blood pressure; plasma Cu and increased triglycerides and body mass index; and urine Zn and increased glucose. Moreover, in the joint exposure analysis using quantile g-computation and TERS, the combined plasma levels of Zn, Cu, Se (directly), and Mn (inversely) were strongly associated with hypercholesterolemia (OR: 2.03; 95%CI: 1.37–2.99; p < 0.001 per quartile increase in the g-computation approach). The analysis of urine mixtures revealed a significant relationship with both fasting glucose and diabetes (OR: 1.91; 95%CI: 1.01–3.04; p = 0.046). In conclusion, in this Mediterranean population, the combined effect of higher plasma trace element levels (primarily Se, Cu, and Zn) was directly associated with elevated plasma lipids, whereas the mixture effect in urine was primarily associated with plasma glucose. Both parameters are relevant cardiovascular risk factors, and increased trace element exposures should be considered with caution. [-]
Publicat a
Antioxidants, 2022, vol. 11, no 10Entitat finançadora
Instituto de Salud Carlos III | Ministerio de Economía y Competitividad | Junta de Andalucía | Generalitat Valenciana | Ministerio de Ciencia, Innovación y Universidades | European Regional Development Fund
Identificador de l'entitat finançadora
http://dx.doi.org/10.13039/501100011033
Codi del projecte o subvenció
CIBER 06/03 | SAF2016–80532-R | PROMETEO2017/01 | APOSTD/2019/136 | PROMETEO/2021/021 | MICIU/ICTI2017-2020/PID2019-108858RB-I00 | AGR145
Títol del projecte o subvenció
https://www.mdpi.com/article/10.3390/antiox11101991/s1
Drets d'accés
info:eu-repo/semantics/openAccess
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