A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
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comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadata
Title
A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisalAuthor (s)
Date
2022-10-03Publisher
Cambridge University PressBibliographic citation
De la Peña-Arteaga V, Morgado P, Couto B, Ferreira S, Castro I, Sousa N, Soriano-Mas C, Picó-Pérez M (2022). A functional magnetic resonance imaging study of frontal networks in obsessivecompulsive disorder during cognitive reappraisal. European Psychiatry, 65(1), e62, 1–8 https://doi.org/10.1192/j.eurpsy.2022.2322Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Background
Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. ... [+]
Background
Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD.
Methods
Adult patients with OCD (n = 31) and healthy controls (HC; n = 30) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored.
Results
Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network.
Conclusions
The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective. [-]
Is part of
European Psychiatry, 65(1), 2022Funder Name
ICVS, member of the national infrastructure PPBI—Portuguese Platform of Bioimaging | Foundation for Science and Technology (FCT), Portugal | Norte Portugal Regional Operational Programme | PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) | 2CA-Clinical Academic Center (Braga, Portugal) | Carlos III Health Institute, Spain
Project code
PPBI-POCI-01-0145-FEDER-022122 | UIDB/50026/2020 | UIDP/50026/2020 | NORTE-01-0145-FEDER-000039 | NORTE 2020 | PI19/01171
Project title or grant
Influence of individual differences in reward sensitivity on the modulation of cognitive motivational interactions in patients with obsessive compulsive disorder
Rights
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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info:eu-repo/semantics/openAccess
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- PSB_Articles [1321]