A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
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INVESTIGACIONMetadades
Títol
A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisalAutoria
Data de publicació
2022-10-03Editor
Cambridge University PressCita bibliogràfica
De la Peña-Arteaga V, Morgado P, Couto B, Ferreira S, Castro I, Sousa N, Soriano-Mas C, Picó-Pérez M (2022). A functional magnetic resonance imaging study of frontal networks in obsessivecompulsive disorder during cognitive reappraisal. European Psychiatry, 65(1), e62, 1–8 https://doi.org/10.1192/j.eurpsy.2022.2322Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Background
Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. ... [+]
Background
Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD.
Methods
Adult patients with OCD (n = 31) and healthy controls (HC; n = 30) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored.
Results
Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network.
Conclusions
The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective. [-]
Publicat a
European Psychiatry, 65(1), 2022Entitat finançadora
ICVS, member of the national infrastructure PPBI—Portuguese Platform of Bioimaging | Foundation for Science and Technology (FCT), Portugal | Norte Portugal Regional Operational Programme | PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) | 2CA-Clinical Academic Center (Braga, Portugal) | Carlos III Health Institute, Spain
Codi del projecte o subvenció
PPBI-POCI-01-0145-FEDER-022122 | UIDB/50026/2020 | UIDP/50026/2020 | NORTE-01-0145-FEDER-000039 | NORTE 2020 | PI19/01171
Títol del projecte o subvenció
Influence of individual differences in reward sensitivity on the modulation of cognitive motivational interactions in patients with obsessive compulsive disorder
Drets d'accés
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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