Enhancement of photoactivity and cellular uptake of (Bu4N)2[Mo6I8(CH3COO)6] complex by loading on porous MCM-41 support. Photodynamic studies as an anticancer agent
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Other documents of the author: de la Torre, Cristina; Gavara, Raquel; García-Fernández, Alba; Mikhaylov, Maxim; Sokolov, Maxim N.; Miravet, Juan; Sancenón, Félix; Martínez Máñez, Ramón; Galindo, Francisco
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comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadata
Title
Enhancement of photoactivity and cellular uptake of (Bu4N)2[Mo6I8(CH3COO)6] complex by loading on porous MCM-41 support. Photodynamic studies as an anticancer agentAuthor (s)
Date
2022-09Publisher
ElsevierISSN
2772-9508Bibliographic citation
de la Torre, C., Gavara, R., García-Fernández, A., Mikhaylov, M., Sokolov, M. N., Miravet, J. F., Sancenón, F., Martínez-Máñez, R., & Galindo, F. (2022). Enhancement of photoactivity and cellular uptake of (Bu4N)2[Mo6I8(CH3COO)6] complex by loading on porous MCM-41 support. Photodynamic studies as an anticancer agent. Biomaterials advances, 140, 213057. https://doi.org/10.1016/j.bioadv.2022.213057Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S277295082200334XVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
The incorporation by ionic assembly of the hexanuclear molybdenum cluster (Bu4N)2[Mo6I8(CH3CO2)6] (1) in amino-decorated mesoporous silica nanoparticles MCM-41, has yielded the new molybdenum-based hybrid photosensitizer ... [+]
The incorporation by ionic assembly of the hexanuclear molybdenum cluster (Bu4N)2[Mo6I8(CH3CO2)6] (1) in amino-decorated mesoporous silica nanoparticles MCM-41, has yielded the new molybdenum-based hybrid photosensitizer 1@MCM-41. The new photoactive material presents a high porosity, due to the intrinsic high specific surface area of MCM-41 nanoparticles (989 m2 g-1) which is responsible for the good dispersion of the hexamolybdenum clusters on the nanoparticles surface, as observed by STEM analysis. The hybrid photosensitizer can generate efficiently singlet oxygen, which was demonstrated by using the benchmark photooxygenation reaction of 9,10-anthracenediyl-bis(methylene)dimalonic acid (ABDA) in water. The photodynamic therapy activity has been tested using LED light as an irradiation source (λirr ~ 400-700 nm; 15.6 mW/cm2). The results show a good activity of the hybrid photosensitizer against human cervical cancer (HeLa) cells, reducing up to 70 % their viability after 20 min of irradiation, whereas low cytotoxicity is detected in the darkness. The main finding of this research is that the incorporation of molybdenum complexes at porous MCM-41 supports enhances their photoactivity and improves cellular uptake, compared to free clusters. [-]
Is part of
Biomaterials Advances, 2022, vol. 140Funder Name
Ministerio de Ciencia, Innovación y Universidades | Universitat Jaume I | Generalitat Valenciana | Ministry of Science and Higher Education of the Russian Federation (M.N.S.)
Funder ID
http://dx.doi.org/10.13039/501100011033
Project code
MICIU/ICTI2017-2020/RTI2018-101675-B-I00 | UJI-B2021-51 | MICIU/ICTI2017-2020/RTI2018-100910-B-C41 | PROMETEO 2018/024 | APOSTD/2019/121 | POSTDOC-B/2018/09
Project title or grant
Nanogeles moleculares que responden a estímulos químicos como ... y liberación de agentes de terapia fotodinámica y biosensores fluorescentes | Materiales porosos inteligentes multifuncionales y dispositivos electrónicos para la liberación de fármacos, detección de drogas y biomarcadores y comunicación a nanoescala
Rights
info:eu-repo/semantics/openAccess
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