Role of Perineuronal nets in the cerebellar cortex in cocaine-induced conditioned preference, extinction, and reinstatement
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Otros documentos de la autoría: Guarque-Chabrera, Julian; Sanchez-Hernandez, Aitor; Ibáñez-Marín, Patricia; Melchor Eixea, Ignasi; MIQUEL, MARTA
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Título
Role of Perineuronal nets in the cerebellar cortex in cocaine-induced conditioned preference, extinction, and reinstatementAutoría
Fecha de publicación
2022-08-17Editor
Elsevier LtdISSN
0028-3908Cita bibliográfica
Guarque-Chabrera, J., Sanchez-Hernandez, A., Ibáñez-Marín, P., Melchor-Eixea, I., & Miquel, M. (2022). Role of Perineuronal nets in the cerebellar cortex in cocaine-induced conditioned preference, extinction, and reinstatement. Neuropharmacology, 218, 109210.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Perineuronal nets (PNNs) are cartilage-like structures of extracellular matrix molecules that enwrap in a net-like manner the cell-body and proximal dendrites of special subsets of neurons. PNNs stabilize their incoming ... [+]
Perineuronal nets (PNNs) are cartilage-like structures of extracellular matrix molecules that enwrap in a net-like manner the cell-body and proximal dendrites of special subsets of neurons. PNNs stabilize their incoming connections and restrict plasticity. Consequently, they have been proposed as a candidate mechanism for drug-induced learning and memory. In the cerebellum, PNNs surround Golgi inhibitory interneurons and both inhibitory and excitatory neurons in the deep cerebellar nuclei (DCN). Previous studies from the lab showed that cocaine-induced conditioned memory increased PNN expression in the granule cell layer of the posterior vermis. The present research aimed to investigate the role of cerebellar PNNs in cocaine-induced conditioned preference. For this purpose, we use the enzyme chondroitinase ABC (ChABC) to digest PNNs at different time points of the learning process to ascertain whether their removal can affect drug-induced memory. Our results show that PNN digestion using ChABC in the posterior vermis (Lobule VIII) did not affect the acquisition of cocaine-induced conditioned preference. However, the removal of PNNs in Lobule VIII -but not in the DCN- disrupted short-term memory of conditioned preference. Moreover, although PNN digestion facilitated the formation of extinction, reinstatement of cocaine-induced conditioned preference was encouraged under PNN digestion. The present findings suggests that PNNs around Golgi interneurons are needed to maintain cocaine-induced Pavlovian memory but also to stabilize extinction memory. Conversely, PNN degradation within the DCN did not affect stability of cocaine-induced memories. Therefore, degradation of PNNs in the vermis might be used as a promising tool to manipulate drug-induced memory. [-]
Publicado en
Neuropharmacology, Vol. 218 (November 2022)Entidad financiadora
Universitat Jaume I | Ministerio de Ciencia e Innovación (España) | Conselleria d'Innovació, Universitats, Ciència i Societat Digital (PIM)
Código del proyecto o subvención
UJI-B2020-1 | PND-132400 | PGC2018-095980-B-I00 | BES-2016-076353 | MCIN/AEI/10.13039/501100011033 | ACIF/2019/109 | PRE2019-088521
Título del proyecto o subvención
Plan de promoción de la investigación (MM) | Plan Nacional de Drogas 2017 (MM) | ERDF A way of making Europe (MM) | ESF investing in your future (ASH) | ESF investing in your future (IME)
Derechos de acceso
© 2022 The Authors. Published by Elsevier Ltd.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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