2-Methyl-6-(phenylethynyl)pyridine Hydrochloride Modulates Metabotropic Glutamate 5 Receptors Endogenously Expressed in Zebrafish Brain
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Altres documents de l'autoria: Albasanz, José Luis; Santana, Soraya; Guzman-Sanchez, Fernando; León, David; Burgos, Javier S.; Martín, Mairena
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadades
Títol
2-Methyl-6-(phenylethynyl)pyridine Hydrochloride Modulates Metabotropic Glutamate 5 Receptors Endogenously Expressed in Zebrafish BrainAutoria
Data de publicació
2016-12-21Editor
American Chemical SocietyISSN
1948-7193Cita bibliogràfica
Albasanz, J. L., Santana, S., Guzman-Sanchez, F., León, D., Burgos, J. S., and Martín, M. (2016) 2-Methyl-6-(phenylethynyl)pyridine Hydrochloride Modulates Metabotropic Glutamate 5 Receptors Endogenously Expressed in Zebrafish Brain. ACS Chem. Neurosci. , 7, 12, 1690-1697 DOI: 10.1021/acschemneuro.6b00213Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://pubs.acs.org/doi/full/10.1021/acschemneuro.6b00213Versió
info:eu-repo/semantics/acceptedVersionParaules clau / Matèries
Resum
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer’s disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors ... [+]
Due to phylogenetic proximity to the human, zebrafish has been recognized as a reliable model to study Alzheimer’s disease (AD) and other central nervous system disorders. Furthermore, metabotropic glutamate receptors have been previously reported to be impaired in brain from AD patients. Metabotropic glutamate 5 (mGlu5) receptors are G-protein coupled receptors proposed as potential targets for therapy of different neurodegenerative disorders. Thus, MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride), a selective noncompetitive mGlu5 receptor antagonist, has been suggested for pharmacological treatment of AD. The aim of the present work was to quantify mGlu5 receptors in brain from zebrafish and to study the possible modulation of these receptors by MPEP treatment. To this end, radioligand binding assay and open field test were used. Results showed a slightly higher presence of mGlu5 receptors in brain from male than in that from female zebrafish. However, a significant increase of mGlu5 receptor in male without variation in female was observed after MPEP treatment. This gender specific response was also observed in locomotor behavior, being significantly decreased only in male zebrafish. These results confirm the presence of mGlu5 receptors in brain from zebrafish and their gender specific modulation by selective antagonist treatment and suggest a role of these receptors on locomotor activity, which is affected in many disorders. In addition, our data point to zebrafish as a useful model to study mGlu receptor function in both healthy and pathological conditions. [-]
Publicat a
ACS Chemical Neuroscience, 2016, vol. 7, no 12Entitat finançadora
Ministerio de Economía y Competitividad (España)
Identificador de l'entitat finançadora
http://dx.doi.org/10.13039/501100004837
Codi del projecte o subvenció
BFU2011-23034 | PEII-2014-030-P
Títol del projecte o subvenció
Control de la neuromodulación de las vías mediadas por los receptores de adenosina y metabotrópicos de glutamato: potencial terapéutico en enfermedades neurodegenerativas | Regulación de receptores de adenosina y
metabotrópicos de glutamato durante el envejecimiento:
implicación en procesos de degeneración y muerte
celular.
Drets d'accés
Copyright © American Chemical Society
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
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