Brain networks alterations in cocaine use and gambling disorders during emotion regulation
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Títol
Brain networks alterations in cocaine use and gambling disorders during emotion regulationAutoria
Data de publicació
2022Editor
Akadémiai KiadóISSN
2062-5871; 2063-5303Cita bibliogràfica
Picó-Pérez M, Costumero V, Verdejo-Román J, Albein-Urios N, Martínez-González JM, Soriano-Mas C, Barrós-Loscertales A, Verdejo-Garcia A. Brain networks alterations in cocaine use and gambling disorders during emotion regulation. J Behav Addict. 2022 Apr 22;11(2):373–85. doi: 10.1556/2006.2022.00018. Epub ahead of print. PMID: 35460545; PMCID: PMC9295223.Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Background: Cocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they ... [+]
Background: Cocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they also exhibit differential aspects, such as the neuroadaptive effects of long-term drug consumption in CUD as compared to GD. Neuroimaging research aimed at disentangling their shared and specific alterations can contribute to improve understanding of both disorders.
Methods: We compared CUD (N = 15), GD (N = 16) and healthy comparison (HC; N = 17) groups using a network-based approach for studying temporally coherent functional networks during functional magnetic resonance imaging (fMRI) of an emotion regulation task. We focused our analysis in limbic, ventral frontostriatal, dorsal attentional (DAN) and executive networks (FPN), given their involvement in emotion regulation and their alteration in CUD and GD. Correlations with measures of emotional experience and impulsivity (UPPS-P) were also performed.
Results: The limbic network was significantly decreased during emotional processing both for CUD and GD individuals compared to the HC group. Furthermore, GD participants compared to HC showed an increased activation in the ventral frontostriatal network during emotion regulation. Finally, networks' activation patterns were modulated by impulsivity traits.
Conclusions: Functional network analyses revealed both overlapping and unique effects of stimulant and gambling addictions on neural networks underpinning emotion regulation. [-]
Publicat a
Journal of Behavioral Addictions 2022 Apr 22;11(2):373–85Entitat finançadora
NORTE 2020 (2014–2020 North Portugal Regional Operational Programme) | Spanish Ministry of Science and Innovation | Medical Research Future Fund | Universitat Jaume I | European Union - NextGenerationEU
Codi del projecte o subvenció
NORTE-01-0145-FEDER-000013 | NORTE-01-0145-FEDER-000023 | PID2019-105077RJ-I00/AEI/10.13039/ 501100011033 | IJC2019-041916-I | MRF1141214 | UJI-B2020-23 | MAZ/2021/11
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info:eu-repo/semantics/openAccess
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