Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding
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https://doi.org/10.1002/jeab.754 |
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Título
Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice respondingAutoría
Fecha de publicación
2022-03-28Editor
Society for the Experimental Analysis of Behavior; WileyISSN
0022-5002; 1938-3711Cita bibliográfica
Ren, N., Carratala‐Ros, C., Ecevitoglu, A., Rotolo, R. A., Edelstein, G. A., Presby, R. E., ... & Salamone, J. D. (2022). Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort‐related choice responding. Journal of the Experimental Analysis of Behavior, 117(3), 331-345.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, ... [+]
The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats were tested on a concurrent fixed ratio 5/chow feeding choice task, in which high-carbohydrate Bio-serv pellets reinforced lever pressing and lab chow was concurrently available. Detailed timing of lever pressing was monitored with an event recording system, and the temporal characteristics of operant behavior seen after 1.0 mg/kg tetrabenazine or vehicle injections were analyzed. Tetrabenazine shifted choice, decreasing lever pressing but increasing chow intake. There was a small effect on the interresponse-time distribution within ratios, but marked increases in the total duration of pauses in responding. The postreinforcement-pause (PRP) distribution was bimodal, but tetrabenazine did not increase the duration of PRPs. Tetrabenazine increased time feeding and duration and number of feeding bouts, but did not affect feeding rate or total time spent lever pressing for pellets and consuming chow. Thus, TBZ appears to predominantly affect the relative allocation of lever pressing versus chow, with little alteration in consummatory motor acts involved in chow intake. Tetrabenazine is used to model motivational symptoms in psychopathology, and these effects in rats could have implications for psychiatric research. [-]
Publicado en
Journal of the Experimental Analysis of Behavior, 2022,117,331–345Datos relacionados
https://onlinelibrary.wiley.com/doi/10.1002/jeab.754#pane-pcw-figuresEntidad financiadora
US National Institute of Mental Health (NIMH) | US National Institutes of Health (NIH)
Código del proyecto o subvención
MH121350
Derechos de acceso
© 2022 Society for the Experimental Analysis of Behavior.
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