A ciliopathy complex builds distal appendages to initiate ciliogenesis
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Otros documentos de la autoría: Kumar, Dhivya; Rains, Addison; Herranz-Pérez, Vicente; Lü, Quanlong; Shi, Xiaoyu; Swaney, Danielle; Stevenson, Erica; Krogan, Nevan; Huang, Bo; Westlake, Christopher; García-Verdugo, Jose Manuel; Yoder, Bradley; Reiter, Jeremy
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Título
A ciliopathy complex builds distal appendages to initiate ciliogenesisAutoría
Fecha de publicación
2021-07-09Editor
Rockefeller University PressISSN
0021-9525; 1540-8140Cita bibliográfica
Dhivya Kumar, Addison Rains, Vicente Herranz-Pérez, Quanlong Lu, Xiaoyu Shi, Danielle L. Swaney, Erica Stevenson, Nevan J. Krogan, Bo Huang, Christopher Westlake, Jose Manuel Garcia-Verdugo, Bradley K. Yoder, Jeremy F. Reiter; A ciliopathy complex builds distal appendages to initiate ciliogenesis. J Cell Biol 6 September 2021; 220 (9): e202011133. doi: https://doi.org/10.1083/jcb.202011133Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and superresolved imaging, we identify a module that we term DISCO (distal centriole complex). The DISCO ... [+]
Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and superresolved imaging, we identify a module that we term DISCO (distal centriole complex). The DISCO components CEP90, MNR, and OFD1 underlie human ciliopathies. This complex localizes to both distal centrioles and centriolar satellites, proteinaceous granules surrounding centrioles. Cells and mice lacking CEP90 or MNR do not generate cilia, fail to assemble distal appendages, and do not transduce Hedgehog signals. Disrupting the satellite pools does not affect distal appendage assembly, indicating that it is the centriolar populations of MNR and CEP90 that are critical for ciliogenesis. CEP90 recruits the most proximal known distal appendage component, CEP83, to root distal appendage formation, an early step in ciliogenesis. In addition, MNR, but not CEP90, restricts centriolar length by recruiting OFD1. We conclude that DISCO acts at the distal centriole to support ciliogenesis by restraining centriole length and assembling distal appendages, defects in which cause human ciliopathies. [-]
Publicado en
J. Cell Biol. 2021 Vol. 220 No. 9Entidad financiadora
National Institutes of Health | Generalitat Valenciana | Ministerio de Ciencia, Innovación y Universidades (Spain) | University of California
Código del proyecto o subvención
R01HD089918 | R01R01DE029454 | R01AR054396 | K99GM126136/R00GM126136 | R01GM124334 | PROMETEO/2019/075 | PCI2018-093062
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info:eu-repo/semantics/openAccess
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Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2021 Kumar et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the
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