The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
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Altres documents de l'autoria: Mateu, Cesar; Rodríguez-Arias, Marta; Gil-Miravet, Isis; Benito, Ana; Tomas, Jose Manuel; Haro, Gonzalo
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INVESTIGACIONMetadades
Títol
The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in PolyconsumersAutoria
Data de publicació
2021-10Editor
MDPIISSN
2076-3425Cita bibliogràfica
Mateu, C.; Rodríguez-Arias, M.; Gil-Miravet, I.; Benito, A.; Tomás, J.M.; Haro, G. The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers. Brain Sci. 2021, 11, 1265. https://doi.org/10.3390/brainsci11101265Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.mdpi.com/2076-3425/11/10/1265Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Descripció
Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) ... [+]
Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders. [-]
Publicat a
Brain Sciences, 2021, vol. 11, no 10Entitat finançadora
Centro Superior de Investigación en Salud Pública (CSISP) | Generalitat Valenciana | Research Foundation of the Hospital Provincial de Castellón
Codi del projecte o subvenció
CS2003-05-05 | T4591000 | CAF 15-049 | CAF 21-026
Drets d'accés
info:eu-repo/semantics/openAccess
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- MED_Articles [646]
Except where otherwise noted, this item's license is described as Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).