Open chain pseudopeptides as hydrogelators with reversible and dynamic responsiveness to pH, temperature and sonication as vehicles for controlled drug delivery
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Título
Open chain pseudopeptides as hydrogelators with reversible and dynamic responsiveness to pH, temperature and sonication as vehicles for controlled drug deliveryFecha de publicación
2022-01-25Editor
ElsevierISSN
0167-7322Cita bibliográfica
Valls, A., Burguete, M. I., Kuret, L., Altava, B., & Luis, S. V. (2022). Open chain pseudopeptides as hydrogelators with reversible and dynamic responsiveness to pH, temperature and sonication as vehicles for controlled drug delivery. Journal of Molecular Liquids, 348, 118051.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
A new family of open chain-pseudopeptidic compounds displaying a pendant carboxylic group have been prepared with excellent yields. Their self-assembly has been studied under different conditions and in different ... [+]
A new family of open chain-pseudopeptidic compounds displaying a pendant carboxylic group have been prepared with excellent yields. Their self-assembly has been studied under different conditions and in different media. Some of the compounds obtained have revealed to act as very efficient hydrogelators at low concentrations (CGC 1 mg mL−1). The resulting hydrogels show some interesting properties, including a high thermal stability, with the hydrogels maintaining their structure at temperatures above 65 °C, and their reversible dynamic sol–gel behavior being responsive to thermal and sonochemical inputs and to changes in the basic/acidic properties of the medium. Preliminary studies for controlled drug delivery have been carried out using a Franz Cell and employing a skin pig membrane, confirming that these Low Molecular Weight Gelators (LMWGs) can be appropriate vehicles for the controlled transdermal delivery of small-molecule drugs. [-]
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Journal of Molecular Liquids, 348 (2022) 118051Datos relacionados
https://ars.els-cdn.com/content/image/1-s2.0-S0167732221027768-mmc1.pdfEntidad financiadora
Ministerio de Ciencia, Innovación y Universidades (Spain) | Universitat Jaume I
Código del proyecto o subvención
RTI2018-098233-B-C22 | UJI-B2019-40 | AICO/2021/139 | FPU15/01191
Derechos de acceso
info:eu-repo/semantics/openAccess
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