A Fast 0.5 T Prepolarizer Module for Preclinical Magnetic Resonance Imaging
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Other documents of the author: Rigla Pérez, Juan Pablo; Borreguero Morata, Jose; Gramage, Carlos; Pallás, Eduardo; González, José M.; Bosch, Rubén; Algarín, José M.; Sanchez-Andres, Juan V.; Galve, Fernando; Grau-Ruiz, Daniel; Pellicer, Rubén; Ríos, Alfonso; Benlloch-Rodriguez, Jose M.; Alonso, Joseba
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Title
A Fast 0.5 T Prepolarizer Module for Preclinical Magnetic Resonance ImagingAuthor (s)
Date
2021-05-17Publisher
IEEEBibliographic citation
J. P. Rigla et al., "A Fast 0.5 T Prepolarizer Module for Preclinical Magnetic Resonance Imaging," in IEEE Transactions on Magnetics, doi: 10.1109/TMAG.2021.3080840.Type
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Abstract
We present a magnet and high power electronics for Prepolarized Magnetic Resonance Imaging (PMRI) in a home-made, special-purpose preclinical system designed for simultaneous visualization of hard and soft biological ... [+]
We present a magnet and high power electronics for Prepolarized Magnetic Resonance Imaging (PMRI) in a home-made, special-purpose preclinical system designed for simultaneous visualization of hard and soft biological tissues. The sensitivity of MRI systems grows with field strength, but so do their costs. PMRI can boost the signal-to-noise ratio (SNR) in affordable low-field scanners by means of a long and strong magnetic pulse. However, this must be rapidly switched off prior to the imaging pulse sequence, in timescales shorter than the spin relaxation (or T1) time of the sample. We have operated our prepolarizer at up to 0.5 T and demonstrated enhanced magnetization, image SNR and tissue contrast with PMRI of tap water, an ex vivo mouse brain and food samples. These have T1 times ranging from hundreds of milli-seconds to single seconds, while the preliminary high-power electronics setup employed in this work can switch off the prepolarization field in tens of milli-seconds. In order to make this system suitable for solid-state matter and hard tissues, which feature T1 times as short as 10 ms, we are developing new electronics which can cut switching times to ~ 300 μs. This does not require changes in the prepolarizer module, opening the door to the first experimental demonstration of PMRI on hard biological tissues. [-]
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IEEE Transactions on Magnetics, 2021Funder Name
European Comission | Ministerio de Ciencia e Innovación (Spain) | Universitat Jaume I | Fundació per al Foment de la Investigació Sanitària i Biomédica de la Comunitat Valenciana (FISABIO) | UJISABIO. Programa de col·laboració UJI-FISABIO | European Union. Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014- 2020 | Agencia Valenciana de la Innovación. Innodocto program
Project code
737180 | PID2019- 111436RB-C21 | IDIFEDER/2018/022 | INNTA3/2020/22 | 21I044.01/1
Project title or grant
FET-Open: HistoMRI
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