Rapid and sensitive analytical method for the determination of amoxicillin and related compounds in water meeting the requirements of the European union watch list
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Title
Rapid and sensitive analytical method for the determination of amoxicillin and related compounds in water meeting the requirements of the European union watch listAuthor (s)
Date
2021-10-07Publisher
ElsevierISSN
0021-9673Bibliographic citation
FABREGAT-SAFONT, David, et al. Rapid and sensitive analytical method for the determination of amoxicillin and related compounds in water meeting the requirements of the European union watch list. Journal of Chromatography A, 2021, vol. 1658, p. 462605.Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
The presence of antibiotics in the aquatic environment is becoming one of the main research focus of scientists and policy makers. Proof of that is the inclusion of four antibiotics, amongst which is amoxicillin,
in ... [+]
The presence of antibiotics in the aquatic environment is becoming one of the main research focus of scientists and policy makers. Proof of that is the inclusion of four antibiotics, amongst which is amoxicillin,
in the EU Watch List (WL) (Decision 2020/1161/EU)) of substances for water monitoring. The accurate
quantification of amoxicillin in water at the sub-ppb levels required by the WL is troublesome due to
its physicochemical properties. In this work, the analytical challenges related to the determination of
amoxicillin, and six related penicillins (ampicillin, cloxacillin, dicloxacillin, penicillin G, penicillin V and
oxacillin), have been carefully addressed, including sample treatment, sample stability, chromatographic
analysis and mass spectrometric detection by triple quadrupole. Given the low recoveries obtained using different solid-phase extraction cartridges, we applied the direct injection of water samples using a
reversed-phase chromatographic column that allowed working with 100% aqueous mobile phase. Matrix
effects were evaluated and corrected using the isotopically labelled internal standard or correction factors
based on signal suppression observed in the analysis of spiked samples.
The methodology developed was satisfactorily validated at 50 and 500 ng L − 1 for the seven penicillins studied, and it was applied to different types of water matrices, revealing the presence of ampicillin in one surface water sample and cloxacillin in three effluent wastewater samples. [-]
Is part of
Journal of Chromatography A 1658 (2021) 462605Funder Name
Ministerios de Ciencia e Innovación y de Universidades | Generalitat Valenciana | Ministerio de Educación, Cultura y Deporte | “la Caixa” Foundation
Project code
RTI2018–097417-B-100 | Research Group of Excellence Prometeo 2019/040 | FPU15/02033 | ID 100010434 | LCF/BQ/PR21/11840012
Rights
info:eu-repo/semantics/openAccess
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