A Meta-analytic Review: Psychological Treatment of Subthreshold Depression in Children and Adolescents
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Other documents of the author: Cuijpers, Pim; Pineda, Blanca; Ng, Mei Yi; Weisz, John; Muñoz, Ricardo F.; Gentili, Claudio; Quero, Soledad; Karyotaki, Eirini
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
A Meta-analytic Review: Psychological Treatment of Subthreshold Depression in Children and AdolescentsAuthor (s)
Date
2021-02-14Publisher
ElsevierISSN
0890-8567Bibliographic citation
CUIJPERS, Pim, et al. A Meta-analytic Review: Psychological Treatment of Subthreshold Depression in Children and Adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 2021.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/journal/journal-of-the-american-academy-of-child-a ...Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Objective: Subthreshold depression has been found to be associated with considerable impairment and an increased risk of developing major
depression. Although several randomized trials have examined the effects of ... [+]
Objective: Subthreshold depression has been found to be associated with considerable impairment and an increased risk of developing major
depression. Although several randomized trials have examined the effects of psychological interventions for subthreshold depression in children and
adolescents, no meta-analysis has integrated the results of these trials.
Method: We searched 4 bibliographic databases and included randomized trials comparing psychological interventions with control conditions in
children and adolescents scoring above a cut-off of a depression questionnaire but not meeting diagnostic criteria for major depression (or persistent
depressive disorder) according to a diagnostic interview. Effect sizes and incidence rates of major depression were pooled with random effects metaanalyses.
Results: A total of 12 trials with 1,576 children and adolescents met inclusion criteria. The overall effect size indicating the difference between
treatment and control at post-test was g ¼ 0.38 (95% CI ¼ 0.14–0.63), which corresponds to a number-needed-to-treat (NNT) of 8.4. Heterogeneity
was moderate to high (I
2 ¼ 61; 95% CI ¼ 28–79), and there was significant risk of publication bias (p < .04). The 2 studies in children less than 12
years of age showed nonsignificant effects (g ¼ 0.01; 95% CI ¼ –1.16 to 1.18). We found no significant effect on the incidence of major depression at
follow-up (relative risk ¼ 0.52; 95% CI ¼ 0.25–1.08), although this may be related to low statistical power.
Conclusion: Interventions for subthreshold depression may have positive acute effects in adolescents. There is currently insufficient evidence,
however, that these interventions are effective in children less than 12 years of age, or that they prevent the onset of major depression at follow-up. [-]
Is part of
J Am Acad Child Adolesc Psychiatry2021;60(9):1072–1084.Funder Name
Instituto de Salud Carlos III | Netherlands Organization for Health Research and Development
Project code
ISCIII CB06 03/ 0052 | 019.182SG.001
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info:eu-repo/semantics/openAccess
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- PSB_Articles [1295]