Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Félix Esbrí, Sonia; Miró-Padilla, Anna; Bueichekú, Elisenda; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina; Broseta Torres, Ricardo
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memoryAutoría
Fecha de publicación
2021-04-24Editor
Elsevier ScienceDirectCita bibliográfica
Naiara Aguirre, Álvaro Javier Cruz-Gómez, Sonia Félix Esbrí, Anna Miró-Padilla, Elisenda Bueichekú, Ricardo Broseta-Torres, César Ávila, Carla Sanchis-Segura, Cristina Forn, Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory, Multiple Sclerosis and Related Disorders, Volume 52, 2021, 102976, ISSN 2211-0348Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S2211034821002431Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:
Working memory (WM) deficits are common in multiple sclerosis (MS) patients. Computerized cognitive training may enhance WM capabilities but its efficacy in MS patients has not been sufficiently explore ... [+]
Background:
Working memory (WM) deficits are common in multiple sclerosis (MS) patients. Computerized cognitive training may enhance WM capabilities but its efficacy in MS patients has not been sufficiently explored.
Methods:
This study examines the effects of n-back training on cognitive performance and functional connectivity (FC) in 29 MS patients and 29 healthy controls (HC). Baseline (S1) performance on 2- and 3-back tasks and FC within the fronto-parietal network were assessed before randomly splitting the sample into four subgroups: trained MS (MSt, n = 15), trained HC (HCt, n = 14), untrained MS (MSu, n = 14), and untrained HC (HCu, n = 15). The trained subgroups underwent adaptive n-back training (60 min/day; 4 days) and n-back task performance and FC were reassessed in a second session (S2).
Results:
As revealed by mixed two-way ANOVAs, trained participants (MSt and HCt) exhibited a significant increase in the number of correct responses and significantly reduced reaction times in S2. These performance improvements were accompanied by an increase in FC in the fronto-parietal pathways and statistically significant correlations between both effects were found.
Conclusions:
Computerised WM training results in behavioural and neuroplasticity positive effects that may be useful when trying to prevent or attenuate cognitive decline in MS patients. [-]
Publicado en
Multiple Sclerosis and Related Disorders Volume 52, July 2021Entidad financiadora
Ministerio de Educación, Cultura y Deporte | Universitat Jaume I | Ministerio de Educación | Generalitat Valenciana and the European Social Fund
Código del proyecto o subvención
PSI2015-67285-R | UJI B2017-05 | FPU16/01525 | 2018 APOSTD
Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- PSB_Articles [1325]