Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory
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Other documents of the author: Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Félix Esbrí, Sonia; Miró-Padilla, Anna; Bueichekú, Elisenda; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina; Broseta Torres, Ricardo
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memoryAuthor (s)
Date
2021-04-24Publisher
Elsevier ScienceDirectBibliographic citation
Naiara Aguirre, Álvaro Javier Cruz-Gómez, Sonia Félix Esbrí, Anna Miró-Padilla, Elisenda Bueichekú, Ricardo Broseta-Torres, César Ávila, Carla Sanchis-Segura, Cristina Forn, Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory, Multiple Sclerosis and Related Disorders, Volume 52, 2021, 102976, ISSN 2211-0348Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S2211034821002431Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Background:
Working memory (WM) deficits are common in multiple sclerosis (MS) patients. Computerized cognitive training may enhance WM capabilities but its efficacy in MS patients has not been sufficiently explore ... [+]
Background:
Working memory (WM) deficits are common in multiple sclerosis (MS) patients. Computerized cognitive training may enhance WM capabilities but its efficacy in MS patients has not been sufficiently explored.
Methods:
This study examines the effects of n-back training on cognitive performance and functional connectivity (FC) in 29 MS patients and 29 healthy controls (HC). Baseline (S1) performance on 2- and 3-back tasks and FC within the fronto-parietal network were assessed before randomly splitting the sample into four subgroups: trained MS (MSt, n = 15), trained HC (HCt, n = 14), untrained MS (MSu, n = 14), and untrained HC (HCu, n = 15). The trained subgroups underwent adaptive n-back training (60 min/day; 4 days) and n-back task performance and FC were reassessed in a second session (S2).
Results:
As revealed by mixed two-way ANOVAs, trained participants (MSt and HCt) exhibited a significant increase in the number of correct responses and significantly reduced reaction times in S2. These performance improvements were accompanied by an increase in FC in the fronto-parietal pathways and statistically significant correlations between both effects were found.
Conclusions:
Computerised WM training results in behavioural and neuroplasticity positive effects that may be useful when trying to prevent or attenuate cognitive decline in MS patients. [-]
Is part of
Multiple Sclerosis and Related Disorders Volume 52, July 2021Funder Name
Ministerio de Educación, Cultura y Deporte | Universitat Jaume I | Ministerio de Educación | Generalitat Valenciana and the European Social Fund
Project code
PSI2015-67285-R | UJI B2017-05 | FPU16/01525 | 2018 APOSTD
Rights
info:eu-repo/semantics/openAccess
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