Inhibitors of the PD-L1 protein. A bibliographic review
View/ Open
Metadata
Show full item recordcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98504
comunitat-uji-handle4:
TFG-TFMThis resource is restricted
Metadata
Title
Inhibitors of the PD-L1 protein. A bibliographic reviewAuthor (s)
Tutor/Supervisor; University.Department
Castillo, Raquel; Sancho Llopis, Juan Vicente; Universitat Jaume I. Departament de Química Física i AnalíticaDate
2020-11-13Publisher
Universitat Jaume IAbstract
The possible inhibitors of the programmed cell-1/programmed cell ligand-1(PD-1/PD-L1)
system are going to be exposed in this review. For this purpose, what PD-1 means, where it
can be found and why inhibit it are ... [+]
The possible inhibitors of the programmed cell-1/programmed cell ligand-1(PD-1/PD-L1)
system are going to be exposed in this review. For this purpose, what PD-1 means, where it
can be found and why inhibit it are going to be exposed.
The programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) are two
protein system that form an immune checkpoint (ICP) that has been considered as a significant
cancer therapy target. So, the first definition that has to be identified is cancer.
Cancer is the name given to a group of related diseases in which abnormal cells divide without
control and can invade nearby tissues. In all types of cancer, some of the body's cells begin to
divide without stopping and spread to surrounding tissues, they have unlimited growth and
expands locally by invasion and systematically by metastasis.
Cancer can start almost anywhere in the human body, which is made up of trillions of cells.
Normally, human cells grow and divide to form new cells as the body needs them and when
normal cells die, new cells replace them. However, in cancer, this orderly process goes tousled.
As cells become more and more abnormal, old or damaged cells survive when they should die,
and new cells are form when they are not needed. These extra cells can divide without
interruption and can form masses called tumors1
. This fact is called cancerogenesis (see Figure
1). [-]
Description
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020
Type
info:eu-repo/semantics/bachelorThesisRights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
This item appears in the folowing collection(s)
- Grau en Química [265]