Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen
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Other documents of the author: Martí-Centelles, Rosa; Dolz Pérez, Irene; De la O, Jaciel; Ontoria Oviedo, Imelda; Sepulveda, Pilar; Nebot Carda, Vicent J.; Vicent, Maria J.; Escuder, Beatriu
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https://doi.org/10.1021/acsabm.0c01422 |
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Title
Two-Component Peptidic Molecular Gels for Topical Drug Delivery of NaproxenAuthor (s)
Date
2021-01-05Publisher
American Chemical SocietyBibliographic citation
MARTÍ-CENTELLES, Rosa, et al. Two-Component Peptidic Molecular Gels for Topical Drug Delivery of Naproxen. ACS Applied Bio Materials, 2021, 4.1: 935-944.Type
info:eu-repo/semantics/articlePublisher version
ACS Appl. Bio Mater. 2021, 4, 1Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Transdermal drug delivery (TDD) is an advantageous and effective approach for the localized delivery of drugs; however, overcoming the high impermeability of the outermost layer of skin, the stratum corneum, represents ... [+]
Transdermal drug delivery (TDD) is an advantageous and effective approach for the localized delivery of drugs; however, overcoming the high impermeability of the outermost layer of skin, the stratum corneum, represents a significant challenge to TDD. Herein, we describe a simple and biocompatible platform based on a two-component molecular hydrogel for the transdermal delivery of the non-steroidal anti-inflammatory drug (S)-naproxen. The hydrogel is formed by two amphipathic tetrapeptides bearing aromatic side groups and oppositely-charged residues that co-assemble into fibrillar networks at pH 7.4. We demonstrate that (S)-naproxen, which possesses an aromatic region and an ionizable group, can be effectively loaded into the hydrogel. We characterized drug-loaded hydrogels by NMR and rheology and studied in vitro release under physiologically relevant conditions. Moreover, TDD studies on human skin samples demonstrated a twofold increase in the permeation of (S)-naproxen, which could be advantageous for the localized delivery of the drug. [-]
Funder Name
Spanish Ministry of Science, Technology, and Universities | Universitat Jaume I | Generalitat Valenciana | FEDER funds
Project code
CTQ2016-76287-R | RTC-2017-6465-1 | UJI-2017-22 | I.D-P, grant VALi+d ACIF-2016-021
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© 2021 American Chemical Society
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