Effets of different CPP cue configuration and extinction procedures on acquisition, extinction and reinstatement of cocaine-associated memories
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Title
Effets of different CPP cue configuration and extinction procedures on acquisition, extinction and reinstatement of cocaine-associated memoriesAuthor (s)
Tutor/Supervisor; University.Department
Font Hurtado, Laura; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia.; Pastor Medall, Raúl; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia.Date
2020-09-07Publisher
Universitat Jaume IAbstract
Addiction is a brain disease characterized by compulsive drug-seeking and taking in spite of
aversive consequences, along with craving and relapse even after long periods of abstinence.
Drugs of abuse induce long- ... [+]
Addiction is a brain disease characterized by compulsive drug-seeking and taking in spite of
aversive consequences, along with craving and relapse even after long periods of abstinence.
Drugs of abuse induce long-lasting changes in brain function and structure, through
neuroplastic mechanisms on the learning and memory system that lead to compulsive drugtaking behavior and eventually to addiction. After several drug-context associations, context
re-exposure can activate those associative-memories eliciting physiological responses and
drug-seeking directed behaviors. Thus, drugs of abuse induce an aberrant enhancement and
consolidation of drug-related memories and its activation by context exposure promotes
compulsive drug-directed behaviors. Among all the neural systems involved in the formation
and consolidation of drug-related memories, the noradrenergic system seems to be a critical
component. The NE responds to emotional arousal, novel stimuli or stimuli that represent a
sensory challenge and require attention. Previous data suggests that the agonism of the NE
system improves appetitive and aversive emotional learning. Specifically, the evidence
suggests the implication of the β2-receptors in conditioned memories induced by abused
drugs. The aim of these experiments is twofold; first to compare different CPP configurations
and procedures on acquisition, extinction and reinstatement of cocaine-associated memories.
Second, to explore the effects of the β2-AR agonist CLE, on extinction and reinstatement of
cocaine-induced CPP using the most effective procedure. For the first aim, we used two
different CPP apparatus configurations (one- (A1) or two- (A2) compartment). Also, we used
two different extinction procedures (force- (FE) and choice- (CE) extinction). For the second
goal, we used a wide range of CLE doses following a A2 apparatus configuration and a CE
procedure. [-]
Subject
Màster Universitari en Investigació en Cervell i Conducta | Máster universitario en Investigación en Cerebro y Conducta | Master's Degree in Research on the Brain and Behaviour |
Conditioned place preference | CPP configuration | extinction procedure |
reinstatement | noradrenergic system | clenbuterol
![](/xmlui/themes/Mirage2/images/uji/materia_peq.png)
![](/xmlui/themes/Mirage2/images/uji/materia_peq.png)
Description
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2019/2020.
Type
info:eu-repo/semantics/masterThesisRights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess