Probiotic supplements on oncology patients’ treatment-related side effects: a systematic review of randomized controlled trials
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Other documents of the author: Rodriguez-Arrastia, Miguel; Martinez-Ortigosa, Adrian; Rueda-Ruzafa, Lola; Folch Ayora, Ana; Ropero-Padilla, Carmen
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Title
Probiotic supplements on oncology patients’ treatment-related side effects: a systematic review of randomized controlled trialsAuthor (s)
Date
2021-04-17Publisher
MDPIISSN
1660-4601Bibliographic citation
Rodriguez-Arrastia, M.; Martinez-Ortigosa, A.; Rueda-Ruzafa, L.; Folch Ayora, A.; Ropero-Padilla, C. Probiotic Supplements on Oncology Patients’ Treatment-Related Side Effects: A Systematic Review of Randomized Controlled Trials. Int. J. Environ. Res. Public Health 2021, 18, 4265. https://doi.org/10.3390/ ijerph18084265Type
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Abstract
Cancer affects more than 19.3 million people and has become the second leading cause
of death worldwide. Chemo- and radiotherapy, the most common procedures in these patients,
often produce unpleasant treatment-related ... [+]
Cancer affects more than 19.3 million people and has become the second leading cause
of death worldwide. Chemo- and radiotherapy, the most common procedures in these patients,
often produce unpleasant treatment-related side effects that have a direct impact on the quality
of life of these patients. However, innovative therapeutic strategies such as probiotics are being
implemented to manage these complications. Thus, this study aimed to evaluate the efficacy of
probiotics supplements as a therapeutic strategy in adult oncology treatment-related side effects. A
systematic review of randomized controlled trials was conducted in PubMed, Scielo, ProQuest and
OVID databases up to and including January 2021, following the PRISMA guidelines. The quality of
the included studies was assessed by the Jadad Scale. Twenty clinical trials published between 1988
and 2020 were included in this review. Seventeen studies (85%) revealed predominantly positive
results when using probiotics to reduce the incidence of treatment-related side effects in oncology
patients, while three studies (15%) reported no impact in their findings. This study sheds some light
on the significance of chemotherapy and radiotherapy in altering the composition of gut microbiota,
where probiotic strains may play an important role in preventing or mitigating treatment-related
side effects. [-]
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International Journal of Environmental Research and Public Health. Vol. 18, Iss. 8, Núm. 4265 (April-2 2021)Rights
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