Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic Therapy
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Altres documents de l'autoria: Torres-Martínez, Ana; Bedrina, Begoña; Falomir, Eva; Marín, María J.; Angulo-Pachón, César A.; Galindo, Francisco; Miravet, Juan
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadades
Títol
Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic TherapyAutoria
Data de publicació
2021-04-19Editor
American Chemical SocietyISSN
2576-6422Cita bibliogràfica
Torres-Martinez, A., Bedrina, B., Falomir, E., Marin, M. J., Angulo-Pachon, C. A., Galindo, F., & Miravet, J. F. Non-polymeric nanogels as versatile nanocarriers: Intracellular transport of the photosensitizers Rose Bengal and Hypericin for photodynamic therapy. ACS Applied Bio Materials 2021 4 (4), 3658-3669. https://doi.org/10.1021/acsabm.1c00139Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://pubs.acs.org/doi/abs/10.1021/acsabm.1c00139Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The use of nanocarriers for intracellular transport of actives has been extensively studied in recent years and represents a central area of nanomedicine. The main novelty of this paper lies on the use of nanogels ... [+]
The use of nanocarriers for intracellular transport of actives has been extensively studied in recent years and represents a central area of nanomedicine. The main novelty of this paper lies on the use of nanogels formed by a low-molecular-weight gelator (1). Here, non-polymeric, molecular nanogels are successfully used for intracellular transport of two photodynamic therapy (PDT) agents, Rose Bengal (RB) and hypericin (HYP). The two photosensitizers (PSs) exhibit different drawbacks for their use in clinical applications. HYP is poorly water-soluble, while the cellular uptake of RB is hindered due to its dianionic character at physiological pH values. Additionally, both PSs tend to aggregate precluding an effective PDT. Despite the different nature of these PSs, nanogels from gelator 1 provide, in both cases, an efficient intracellular transport into human colon adenocarcinoma cells (HT-29) and a notably improved PDT efficiency, as assessed by confocal laser scanning microscopy and flow cytometry. Furthermore, no significant dark toxicity of the nanogels is observed, supporting the biocompatibility of the delivery system. The developed nanogels are highly reproducible due to their non-polymeric nature, and their synthesis is easily scaled up. The results presented here thus confirm the potential of molecular nanogels as valuable nanocarriers, capable of entrapping both hydrophobic and hydrophilic actives, for PDT of cancer. [-]
Publicat a
ACS Applied Bio Materials, 2021, vol. 4, no 4Entitat finançadora
Ministerio de Economía y Competitividad (España) | Universitat Jaume I | Ministerio de Educación, Cultura y Deporte (España)
Codi del projecte o subvenció
CTQ2015-71004-R | RTI2018-101675-B-I00 | UJI-B2018-54 | FPU14/05974
Drets d'accés
info:eu-repo/semantics/openAccess
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