Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration
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Other documents of the author: Sanchez-Hernandez, Aitor; Nicolas, Celine; Gil-Miravet, Isis; Guarque-Chabrera, Julian; Solinas, Marcello; MIQUEL, MARTA
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Title
Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administrationAuthor (s)
Date
2021-01-03Publisher
SpringerISSN
0033-3158Bibliographic citation
Sanchez-Hernandez, A., Nicolas, C., Gil-Miravet, I. et al. Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration. Psychopharmacology 238, 1059–1068 (2021). https://doi.org/10.1007/s00213-020-05752-0Type
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007%2Fs00213-020-05752-0Version
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Rationale The probability of structural remodeling in brain circuits may be modulated by molecules of perineuronal nets (PNNs)
that restrict neuronal plasticity to stabilize circuits. Animal research demonstrates ... [+]
Rationale The probability of structural remodeling in brain circuits may be modulated by molecules of perineuronal nets (PNNs)
that restrict neuronal plasticity to stabilize circuits. Animal research demonstrates that addictive drugs can remodel PNNs in
different brain regions, including the cerebellum.
Objective This study aimed to investigate the effects of short versus extended access to cocaine self-administration on PNN
expression around Golgi interneurons in the cerebellar cortex after different periods of abstinence.
Methods After 1 week of training (2 h/day), Sprague-Dawley rats self-administered cocaine daily for 20 days under short (ShA)
or extended (LgA) access. PNN expression in the cerebellum was assessed after 1 day, 7 days, and 28 days of forced abstinence.
PNNs were immunolabeled using Wisteria floribunda agglutinin (WFA) and captured by confocal microscopy.
Results WFA intensity increased in PNN-bearing Golgi neurons over the abstinence period and a higher proportion of more
intense PNNs were formed throughout the first month of abstinence. After the first 24 h of cocaine abstinence, however, we found
a reduction in WFA intensity in the cerebellar cortex of rats with ShA to cocaine as compared to naïve animals. When comparing
with naïve rats, LgA rats showed consistent PNN upregulation at 28 days of cocaine abstinence.
Conclusions Our results suggest that cocaine self-administration produces modifications in PNN that enhance conditions for
synaptic plasticity in the cerebellar cortex. These modifications are revealed shortly after the cessation of drug intake but PNNs
become more intense during protracted abstinence in the LgA group, pointing to the stabilization of drug-induced synaptic
changes. These findings indicate that extended access to cocaine self-administration dynamically regulates conditions for plasticity in the cerebellum during abstinence. [-]
Is part of
Psychopharmacology 238, 1059–1068 (2021)Funder Name
Ministerio de Economía y Competitividad | Universitat Jaume I | Fondation pour la Recherche Medicale
Project code
PSI2015-68600-P | BES-2016-076353 (ASH) | 14I307.01/1 | PREDOC2014/11 (IGM) | FRM, DPA20140629806 grant to MS | PhD fellowship by the Poitou-Charentes region (CN)
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info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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- PSB_Articles [1330]