Pregnancy Changes the Response of the Vomeronasal and Olfactory Systems to Pups in Mice
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Pregnancy Changes the Response of the Vomeronasal and Olfactory Systems to Pups in MiceAutoria
Data de publicació
2020-12-18Editor
Frontiers MediaISSN
1662-5102Cita bibliogràfica
Navarro-Moreno C, Sanchez-Catalan MJ, Barneo-Muñoz M, Goterris-Cerisuelo R, Belles M, Lanuza E, Agustin-Pavon C and Martinez-Garcia F (2020) Pregnancy Changes the Response of the Vomeronasal and Olfactory Systems to Pups in Mice. Front. Cell. Neurosci. 14:593309. doi: 10.3389/fncel.2020.593309Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.frontiersin.org/articles/10.3389/fncel.2020.593309/fullVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Motherhood entails changes in behavior with increased motivation for pups, induced in
part by pregnancy hormones acting upon the brain. This work explores whether this alters
sensory processing of pup-derived ... [+]
Motherhood entails changes in behavior with increased motivation for pups, induced in
part by pregnancy hormones acting upon the brain. This work explores whether this alters
sensory processing of pup-derived chemosignals. To do so, we analyse the expression
of immediate early genes (IEGs) in the vomeronasal organ (VNO; Egr1) and centers of
the olfactory and vomeronasal brain pathways (cFos) in virgin and late-pregnant females
exposed to pups, as compared to buttons (socially neutral control). In pup-exposed
females, we quantified diverse behaviors including pup retrieval, sniffing, pup-directed
attack, nest building and time in nest or on nest, as well as time off nest. Pups induce
Egr1 expression in the VNO of females, irrespective of their physiological condition,
thus suggesting the existence of VNO-detected pup chemosignals. A similar situation
is found in the accessory olfactory bulb (AOB) and posteromedial part of the medial
bed nucleus of the stria terminalis (BSTMPM). By contrast, in the medial amygdala and
posteromedial cortical amygdala (PMCo), responses to pups-vs-buttons are different
in virgin and late-pregnant females, thus suggesting altered sensory processing during
late pregnancy. The olfactory system also shows changes in sensory processing with
pregnancy. In the main olfactory bulbs, as well as the anterior and posterior piriform
cortex, buttons activate cFos expression in virgins more than in pregnant females. By
contrast, in the anterior and especially posterior piriform cortex, pregnant females show
more activation by pups than buttons. Correlation between IEGs expression and behavior
suggests the existence of two vomeronasal subsystems: one associated to pup care
(with PMCo as its main center) and another related to pup-directed aggression observed
in some pregnant females (with the BSTMPM as the main nucleus). Our data also suggest
a coactivation of the olfactory and vomeronasal systems during interaction with pups in
pregnant females. [-]
Publicat a
Front. Cell. Neurosci. 14:593309Entitat finançadora
Spanish Ministry of Economy and Competitiveness-FEDER | Spanish Ministry of Science and Innovation | Generalitat Valenciana | Universitat Jaume I de Castelló
Codi del projecte o subvenció
BFU2016-77691-C2-2-P and C2-1-P | PID2019-107322GB-C21 | PROMETEO/2016/076 | UJI-B2016-45 and UJIA2019-14
Drets d'accés
info:eu-repo/semantics/openAccess
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