Travelling wave ion mobility-derived collision cross section for mycotoxins: Investigating interlaboratory and interplatform reproducibility
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INVESTIGACIONMetadata
Title
Travelling wave ion mobility-derived collision cross section for mycotoxins: Investigating interlaboratory and interplatform reproducibilityAuthor (s)
Date
2020-09-01Publisher
American Chemical SocietyISSN
0021-8561Bibliographic citation
RIGHETTI, Laura, et al. Travelling Wave Ion Mobility-Derived Collision Cross Section for Mycotoxins: Investigating Interlaboratory and Interplatform Reproducibility. Journal of Agricultural and Food Chemistry, 2020, vol. 68, no 39, p. 10937-10943.Type
info:eu-repo/semantics/articlePublisher version
https://pubs.acs.org/doi/10.1021/acs.jafc.0c04498Version
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Parent and modified mycotoxin analysis remains a challenge because of their chemical diversity, the presence of
isomeric forms, and the lack of analytical standards. The creation and application of a collision cross ... [+]
Parent and modified mycotoxin analysis remains a challenge because of their chemical diversity, the presence of
isomeric forms, and the lack of analytical standards. The creation and application of a collision cross section (CCS) database for
mycotoxins may bring new opportunities to overcome these analytical challenges. However, it is still an open question whether
common CCS databases can be used independently from the instrument type and ion mobility mass spectrometry (IM-MS)
technologies, which utilize different methodologies for determining the gas-phase mobility. Here, we demonstrated the
reproducibility of CCS measurements for mycotoxins in an interlaboratory study (average RSD 0.14% ± 0.079) and across different
traveling wave IM-MS (TWIMS) systems commercially available (ΔCCS% < 2). The separation in the drift time dimension of
critical pairs of isomers for modified mycotoxins was also achieved. In addition, the comparison of measured and predicted CCS
values, including regulated and emerging mycotoxins, was addressed. [-]
Is part of
J. Agric. Food Chem. 2020, 68, 39, 10937–10943Investigation project
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© 2020 American Chemical Society
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