Corneal relaxation time estimation as a function of tear oxygen tension in human cornea during contact lens wear
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https://doi.org/10.1002/jbm.b.34360 |
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Título
Corneal relaxation time estimation as a function of tear oxygen tension in human cornea during contact lens wearAutoría
Fecha de publicación
2019-12-03Editor
John Wiley & SonsISSN
1552-4973Cita bibliográfica
Del Castillo, LF, Ramírez‐Calderón, JG, Del Castillo, RM, Aguilella‐Arzo, M, Compañ, V. 2020. Corneal relaxation time estimation as a function of tear oxygen tension in human cornea during contact lens wear. Journal of Biomedical Materials Research Part B Applied Biomaterials. 108(1):14-21Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The purpose is to estimate the oxygen diffusion coefficient and the relaxation time of the cornea with respect to the oxygen tension at the cornea–tears interface. Both findings are discussed. From the experimental ... [+]
The purpose is to estimate the oxygen diffusion coefficient and the relaxation time of the cornea with respect to the oxygen tension at the cornea–tears interface. Both findings are discussed. From the experimental data provided by Bonanno et al., the oxygen tension measurements in vivo for human cornea–tears–contact lens (CL), the relaxation time of the cornea, and their oxygen diffusion coefficient were obtained by numerical calculation using the Monod‐kinetic model. Our results, considering the relaxation time of the cornea, observe a different behavior. At the time less than 8 s, the oxygen diffusivity process is upper‐diffusive, and for the relaxation time greater than 8 s, the oxygen diffusivity process is lower‐diffusive. Both cases depend on the partial pressure of oxygen at the entrance of the cornea. The oxygen tension distribution in the cornea–tears interface is separated into two different zones: one for conventional hydrogels, which is located between 6 and 75 mmHg, with a relaxation time included between 8 and 19 s, and the other zone for silicone hydrogel CLs, which is located at high oxygen tension, between 95 and 140 mmHg, with a relaxation time in the interval of 1.5–8 s. It is found that in each zone, the diffusion coefficient varies linearly with the oxygen concentration, presenting a discontinuity in the transition of 8 s. This could be interpreted as an aerobic‐to‐anaerobic transition. We attribute this behavior to the coupling formalism between oxygen diffusion and biochemical reactions to produce adenosine triphosphate. [-]
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Journal of Biomedical Materials Research Part B Applied Biomaterials, jan. 2020, vol 108 B, issue 1Proyecto de investigación
UNAM-DGAPA-PAPIIT projects IG 100618 and IN-114818, ENE/2015-69203-RDerechos de acceso
© 2019 Wiley Periodicals, Inc.
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