MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes
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Other documents of the author: Albert Gasco, Hector; Ros, Francisco; Castillo-Gómez, Esther; Olucha-Bordonau, Francisco E
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Title
MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative ProcessesAuthor (s)
Date
2020-06-23Publisher
MDPIISSN
1422-0067Bibliographic citation
Albert-Gascó, H.; Ros-Bernal, F.; Castillo-Gómez, E.; Olucha-Bordonau, F.E. MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes. Int. J. Mol. Sci. 2020, 21, 4471.Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/1422-0067/21/12/4471Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information transduction
from extracellular stimuli to the ... [+]
The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information transduction
from extracellular stimuli to the intracellular space. The transduction of information leads to changes
in the ongoing metabolic pathways and the modification of gene expression patterns. In the central
nervous system, ERK is expressed ubiquitously, both temporally and spatially. As for the temporal
ubiquity, this signaling system participates in three key moments: (i) Embryonic development;
(ii) the early postnatal period; and (iii) adulthood. During embryonic development, the system is
partly responsible for the patterning of segmentation in the encephalic vesicle through the FGF8-ERK
pathway. In addition, during this period, ERK directs neurogenesis migration and the final fate of
neural progenitors. During the early postnatal period, ERK participates in the maturation process
of dendritic trees and synaptogenesis. During adulthood, ERK participates in social and emotional
behavior and memory processes, including long-term potentiation. Alterations in mechanisms related
to ERK are associated with different pathological outcomes. Genetic alterations in any component
of the ERK pathway result in pathologies associated with neural crest derivatives and mental
dysfunctions associated with autism spectrum disorders. The MAP-ERK pathway is a key element of
the neuroinflammatory pathway triggered by glial cells during the development of neurodegenerative
diseases, such as Parkinson’s and Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral
sclerosis, as well as prionic diseases. The process triggered by MAPK/ERK activation depends on
the stage of development (mature or senescence), the type of cellular element in which the pathway
is activated, and the anatomic neural structure. However, extensive gaps exist with regards to the
targets of the phosphorylated ERK in many of these processes. [-]
Is part of
Int. J. Mol. Sci. 2020, 21, 4471Investigation project
Fundación Alicia Koplowitz, Spain, grant number 19I436 ; RTI2018-095698-B-I00 ; GV/2019/088(E.C.-G) ; UJI-B2019-54 (F.E.O.-B.) ; UJI-A2017-17 (F.R.-B.);Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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