Becoming stressed: Does the age matter? Reviewing the neurobiological and socio-affective effects of stress throughout the lifespan
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Other documents of the author: Mañas-Ojeda, Aroa; Ros, Francisco; Olucha-Bordonau, Francisco E; Castillo-Gómez, Esther
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Title
Becoming stressed: Does the age matter? Reviewing the neurobiological and socio-affective effects of stress throughout the lifespanDate
2020-08-13Publisher
MDPIISSN
1422-0067Bibliographic citation
Mañas-Ojeda, A.; Ros-Bernal, F.; Olucha-Bordonau, F.E.; Castillo-Gómez, E. Becoming Stressed: Does the Age Matter? Reviewing the Neurobiological and Socio-Affective Effects of Stress throughout the Lifespan. Int. J. Mol. Sci. 2020, 21, 5819.Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/1422-0067/21/16/5819Version
info:eu-repo/semantics/publishedVersionSubject
stress | amygdala | early life | adult | old age | neuronal plasticity | endocannabinoid | anxiety | depression | sociability
Abstract
Social and affective relations occur at every stage of our lives. Impairments in the quality of
this “social world” can be exceptionally detrimental and lead to psychopathology or pathological
behavior, including ... [+]
Social and affective relations occur at every stage of our lives. Impairments in the quality of
this “social world” can be exceptionally detrimental and lead to psychopathology or pathological
behavior, including schizophrenia, autism spectrum disorder, affective disorders, social phobia or
violence, among other things. Exposure to highly stressful or traumatic events, depending on the
stage of life in which stress exposure occurs, could severely affect limbic structures, including the
amygdala, and lead to alterations in social and affective behaviors. This review summarizes recent
findings from stress research and provides an overview of its age-dependent effects on the structure
and function of the amygdala, which includes molecular and cellular changes, and how they can
trigger deviant social and affective behaviors. It is important to highlight that discoveries in this
field may represent a breakthrough both for medical science and for society, as they may help in the
development of new therapeutic approaches and prevention strategies in neuropsychiatric disorders
and pathological behaviors. [-]
Is part of
Int. J. Mol. Sci. 2020, 21, 5819Investigation project
RTI2018-095698-B-I00 ; 19I436 ; GV/2019/088 (E.C.-G) ; UJI-B2019-54 (F.E.O.-B.) ; UJI-A2017-17 (F.R.-B.)Rights
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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