Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic Acid
Impact
Scholar |
Other documents of the author: González, Florenci; Bou Iserte, Lledó; Miguel-López, Borja; de la hoz rodriguez, Sergio; Kersten, Christian; Sánchez-Sarasúa, Sandra; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
comunitat-uji-handle4:
INVESTIGACIONThis resource is restricted
https://doi.org/10.1002/slct.202002294 |
Metadata
Title
Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic AcidAuthor (s)
Date
2020-07-13Publisher
WileyISSN
2365-6549Bibliographic citation
F. V. González, L. Bou-Iserte, B. Miguel-López, S. de la Hoz-Rodríguez, C. Kersten, S. Sánchez-Sarasúa, V. Espinosa-Fernández, A. M. Sánchez-Pérez, ChemistrySelect 2020, 5, 8015.Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side ... [+]
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side chain of abscisic acid happened during the synthesis. The resulting fluorophore analogues derived from both isomeric compounds entered cells suggesting a wide applicability of the ABA‐NBD conjugates as fluorescent probes to study ABA mechanism of action. The functional properties of the isomeric ABA‐NBD conjugates were tested in vitro, by measuring TNFα expression and nitrite concentration in LPS‐stimulated macrophages and compared with their non‐fluorescent ABA isomers. Rationalization of the results is given as supported by docking studies of the compounds with LANCL2 and PPARγ targets. [-]
Is part of
ChemistrySelect, 2020, vol. 5, no 26Investigation project
Universitat Jaume I: UJIB2018-41, UJIB2018-01; Predoctoral Ministerio de Ciencia, Innovación y Universidades: FPU17/06209; Universitat Jaume I: PREDOC\2017\25Rights
Copyright © John Wiley & Sons
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
This item appears in the folowing collection(s)
- QUIO_Articles [694]