Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic Acid
Impacte
Scholar |
Altres documents de l'autoria: González, Florenci; Bou Iserte, Lledó; Miguel-López, Borja; de la hoz rodriguez, Sergio; Kersten, Christian; Sánchez-Sarasúa, Sandra; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María
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https://doi.org/10.1002/slct.202002294 |
Metadades
Títol
Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic AcidAutoria
Data de publicació
2020-07-13Editor
WileyISSN
2365-6549Cita bibliogràfica
F. V. González, L. Bou-Iserte, B. Miguel-López, S. de la Hoz-Rodríguez, C. Kersten, S. Sánchez-Sarasúa, V. Espinosa-Fernández, A. M. Sánchez-Pérez, ChemistrySelect 2020, 5, 8015.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202002294Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side ... [+]
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side chain of abscisic acid happened during the synthesis. The resulting fluorophore analogues derived from both isomeric compounds entered cells suggesting a wide applicability of the ABA‐NBD conjugates as fluorescent probes to study ABA mechanism of action. The functional properties of the isomeric ABA‐NBD conjugates were tested in vitro, by measuring TNFα expression and nitrite concentration in LPS‐stimulated macrophages and compared with their non‐fluorescent ABA isomers. Rationalization of the results is given as supported by docking studies of the compounds with LANCL2 and PPARγ targets. [-]
Publicat a
ChemistrySelect, 2020, vol. 5, no 26Proyecto de investigación
Universitat Jaume I: UJIB2018-41, UJIB2018-01; Predoctoral Ministerio de Ciencia, Innovación y Universidades: FPU17/06209; Universitat Jaume I: PREDOC\2017\25Drets d'accés
Copyright © John Wiley & Sons
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