The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
![Thumbnail](/xmlui/bitstream/handle/10234/190171/2019_Pavan_puz.pdf.jpg?sequence=5&isAllowed=y)
Visualitza/
Impacte
![Google Scholar](/xmlui/themes/Mirage2/images/uji/logo_google.png)
![Microsoft Academico](/xmlui/themes/Mirage2/images/uji/logo_microsoft.png)
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/176601
comunitat-uji-handle3:10234/176618
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?Autoria
Data de publicació
2019Editor
Springer NatureISSN
1743-8977Cita bibliogràfica
Pavan, C., Delle Piane, M., Gullo, M. et al. The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?. Part Fibre Toxicol 16, 32 (2019). https://doi.org/10.1186/s12989-019-0315-3Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-019 ...Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Background: Silica continues to represent an intriguing topic of fundamental and applied research across various
scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The ... [+]
Background: Silica continues to represent an intriguing topic of fundamental and applied research across various
scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of
silica is variable, depending on the physico-chemical features of the particles. In the last 50 years, crystallinity and
capacity to generate free radicals have been recognized as relevant features for silica toxicity. The ‘surface’ also
plays an important role in silica toxicity, but this term has often been used in a very general way, without defining
which properties of the surface are actually driving toxicity. How the chemical features (e.g., silanols and siloxanes)
and configuration of the silica surface can trigger toxic responses remains incompletely understood.
Main body: Recent developments in surface chemistry, cell biology and toxicology provide new avenues to
improve our understanding of the molecular mechanisms of the adverse responses to silica particles. New physicochemical methods can finely characterize and quantify silanols at the surface of silica particles. Advanced
computational modelling and atomic force microscopy offer unique opportunities to explore the intimate
interactions between silica surface and membrane models or cells. In recent years, interdisciplinary research, using
these tools, has built increasing evidence that surface silanols are critical determinants of the interaction between
silica particles and biomolecules, membranes, cell systems, or animal models. It also has become clear that silanol
configuration, and eventually biological responses, can be affected by impurities within the crystal structure, or
coatings covering the particle surface. The discovery of new molecular targets of crystalline as well as amorphous
silica particles in the immune system and in epithelial lung cells represents new possible toxicity pathways. Cellular
recognition systems that detect specific features of the surface of silica particles have been identified.
Conclusions: Interdisciplinary research bridging surface chemistry to toxicology is progressively solving the
puzzling issue of the variable toxicity of silica. Further interdisciplinary research is ongoing to elucidate the intimate
mechanisms of silica pathogenicity, to possibly mitigate or reduce surface reactivity. [-]
Publicat a
Particle and Fibre Toxicology, 2019, 16.Drets d'accés
info:eu-repo/semantics/openAccess
Apareix a les col.leccions
- ITC_Articles [77]
Els següents fitxers sobre la llicència estan associats a aquest element:
Except where otherwise noted, this item's license is described as © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated