Postnatal exposure to mercury and neuropsychological development among preschooler children
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INVESTIGACIONMetadatos
Título
Postnatal exposure to mercury and neuropsychological development among preschooler childrenAutoría
Fecha de publicación
2020-03-13Editor
SpringerCita bibliográfica
LLOP, Sabrina, et al. Postnatal exposure to mercury and neuropsychological development among preschooler children. European Journal of Epidemiology, 2020, v. 35, p. 259–271Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://link.springer.com/article/10.1007/s10654-020-00620-9Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The objective of this study was to describe the postnatal exposure to Hg and to evaluate its association with neuropsychological
development among preschool children. The study population are 4–5 years old children ... [+]
The objective of this study was to describe the postnatal exposure to Hg and to evaluate its association with neuropsychological
development among preschool children. The study population are 4–5 years old children (n = 1252) participant in
the Spanish INMA Project. Total Hg was measured in cord blood and in hair samples taken at 4 years of age (2008–2012).
Neuropsychological development was assessed using the McCarthy Scales of Children’s Abilities (MSCA). Information on
covariates and possible confounders was obtained by questionnaires during pregnancy and childhood. Generalized additive
and linear regression models were built in order to assess the relationship between MSCA scores and Hg exposure. We also
evaluated the magnitude of the possible bias generated from measurement error in seafood intake estimate from questionnaire
and Hg determination. The geometric mean of hair Hg was 0.98 μg/g [95% confidence interval (CI) 0.94, 1.03]. In the regression
analysis, the association between Hg and the MSCA scores was positive for all the scales and statistically significant for
the verbal (β = 0.89; 95%CI 0.38, 1.39), memory (β = 0.42; 95%CI 0.09, 0.76) and general cognitive scales (β = 1.35; 95%CI
0.45, 2.25). However, these associations were clearly attenuated when we adjusted by the children’s fish intake variables or
when took into account theoretical scenarios of low precision in fish intake and Hg measurements. Hg levels in this Spanish
population were high in comparison with other European countries; however, we did not observe adverse effects on child
neuropsychological development associated with this postnatal exposure to Hg. [-]
Publicado en
European Journal of Epidemiology, 2020, v. 35Proyecto de investigación
This study was funded by grants from European Union (FP7- ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: Instituto Carlos III (Red INMA G03/176; CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1436, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI081151, PI09/00090, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/02187, PI13/1944, PI13/2032, PI14/00108, PI14/00891, PI14/01687, PI16/00261, PI16/1288, PI17/00663, and PI19/1338; Miguel Servet-FSE: MS11/0178, MS15/0025, MSII16/0051, MSII19/00015; Miguel Servet-FEDER: CP11/0178 and CP15/0025, co-funded by European Regional Development Fund ‘A way to make Europe’), CIBERESP, Generalitat de Catalunya (CIRIT 1999SGR 00241 and AGAUR 2009 SGR 501), Fundació La marató de TV3 (090430), EU Commission (261357), Generalitat Valenciana, FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221), annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), and Alicia Koplowitz Foundation 2017. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.Derechos de acceso
info:eu-repo/semantics/openAccess
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