The effect of the AKT1 gene and cannabis use on cognitive performance in healthy subjects
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Scholar |
Otros documentos de la autoría: Fatjó-Vilas, Mar; Soler, Jordi; Ibáñez, Manuel I; Moya-Higueras, Jorge; Ortet, Generós; Guardiola-Ripoll, M.; Fañanás Saura, Lourdes; Arias, Barbara
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https://doi.org/10.1177/0269881120928179 |
Metadatos
Título
The effect of the AKT1 gene and cannabis use on cognitive performance in healthy subjectsAutoría
Fecha de publicación
2020-06-13Editor
SageTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://journals.sagepub.com/doi/full/10.1177/0269881120928179Versión
info:eu-repo/semantics/publishedVersionResumen
Background:
Evidence suggests that the AKT1 gene may modulate the degree to which cannabis use induces cognitive alterations in patients with a psychotic disorder.
Aim:
To examine the interplay between AKT1 and ... [+]
Background:
Evidence suggests that the AKT1 gene may modulate the degree to which cannabis use induces cognitive alterations in patients with a psychotic disorder.
Aim:
To examine the interplay between AKT1 and cannabis use in terms of the cognitive performance of the general population.
Methods:
Our sample consisted of 389 Spanish university students. Sustained attention was measured via the Continuous Performance Test–Identical Pairs, immediate and delayed verbal memory with the Logical Memory subtest of the Wechsler Memory Scale, and working memory with the Wisconsin Card Sorting Test. Lifetime cannabis use frequency was assessed and individuals were classified as cannabis users or non-users. Two single nucleotide polymorphisms of the AKT1 gene were genotyped and, according to previous studies, each subject was defined as a carrier of two, one or no copies of the haplotype (rs2494732(C)–rs1130233(A)). Multiple linear regressions were conducted to test the effect of the genetic variability and cannabis use (and their interaction) on cognitive performance.
Results:
An effect of the AKT1 haplotype was found on attention scores: individuals with two copies of the haplotype performed better (β=0.18, p<0.001 (adjusted for false discovery rate)), while neither cannabis nor the AKT1–cannabis interaction was associated with attention. No effect of AKT1, cannabis or the AKT1–cannabis interaction was found on verbal memory or working memory.
Conclusions:
Our study provides additional evidence that AKT1 modulates cognitive performance. However, in our non-clinical sample, the previously reported interaction between cannabis use and the AKT1 gene was not replicated. [-]
Proyecto de investigación
Plan Nacional Sobre Drogas, of the Spanish Ministry of Health (2008/090) ; Instituto de Salud Carlos III through projects PI15/01420 and PI16/00998 (co-funded by the European Regional Development Fund/European Social Fund) (‘Investing in your future’); Spanish Ministry of Science, Innovation and Universities (MICIU/ FEDER_RTI2018-099800-B-I00); Universitat Jaume I (UJI-B2017- 74); the Comissionat per a Universitats i Recerca del DIUE, of the Generalitat de Catalunya regional authorities (2017SGR1577 and 2017SGR1271); Generalitat Valenciana (AICO/2019/197). M Fatjó-Vilas thanks the Instituto de Salud Carlos III for her Sara Borrell contract (CD16/00264) and J Soler thanks the University of Barcelona for his Ajut de Personal Investigador Predoctoral en Formació (APIF).Derechos de acceso
© The Author(s) 2020
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