Genome-wide association analyses of weight loss in a randomized controlled trial of lifestyle intervention, and combined transcriptome-wide associations in a Mediterranean population
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Otros documentos de la autoría: Corella, Dolores; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Fernández-Carrión, Rebeca; Barragán-Arnal, Rocío; González, José I.; Coltell, Oscar
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Título
Genome-wide association analyses of weight loss in a randomized controlled trial of lifestyle intervention, and combined transcriptome-wide associations in a Mediterranean populationAutoría
Fecha de publicación
2019-09-11Editor
European Molecular Biology Organization (EMBO)Tipo de documento
info:eu-repo/semantics/conferenceObjectVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Although large-scale genome-wide association studies (GWAS) for obesity traits have identified more than 400 associated loci from observational studies (Figure 1), we highlight the fact that currently the number of ... [+]
Although large-scale genome-wide association studies (GWAS) for obesity traits have identified more than 400 associated loci from observational studies (Figure 1), we highlight the fact that currently the number of GWAS for intentional weight change in randomized controlled trials (RCT) of lifestyle interventions is very scarce.
Only a few RCT on weight loss have been carried out and recently a GWAS including 2 populations (a Canadian RCT and the Diogenes RCT) was been published (Valsesia et al, Nat Communications, 2019). Likely, at the transcriptome level, there is a scarcity of transcriptome-wide association studies (TWAS) of weight loss in RCT. Moreover, this scarcity is higher for studies including subjects from the Mediterranean countries.
Therefore, our first aim was to undertake a GWAS in overweight/obese subjects from a Mediterranean population (Spain) after 1-year lifestyle intervention (including an energy restricted Mediterranean diet plus physical activity) in a RCT to identify genetic variants associated with weight loss and related outcomes. In addition, as a second aim, we carried out a TWAS in a subsample of subjects for the same intervention to identify changes in gene expression and related pathways. [-]
Descripción
Pòster presentat a EMBO - EMBL Symposia Multiomics to Mechanisms - Challenges in Data Integration. September (11th – 13th 2019 European Molecular Biology Laboratory. Heidelberg, Germany)
Proyecto de investigación
Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER, “A way of making Europe”) (grants CIBER 06/03, PRX17/00500, SAF2016–80532-R) and Premio Rei Jaume I (Valencia, Spain); University Jaume I (grants P1–1B2013–54, COGRUP/2016/06 and UJI-B2018-69); Fundació La Marató de TV3 (grant 538/U/2016); Generalitat Valenciana (grant PROMETEO2017/017).Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
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info:eu-repo/semantics/openAccess