Design of metalloporphyrins fused to imidazolium rings for binding DNA G-quadruplexes
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https://doi.org/10.1142/S1088424619501128 |
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Título
Design of metalloporphyrins fused to imidazolium rings for binding DNA G-quadruplexesAutoría
Fecha de publicación
2020-01Editor
World ScientificCita bibliográfica
CAPORALETTI, Francesca, et al. Design of metalloporphyrins fused to imidazolium rings for binding DNA G-quadruplexes. Journal of Porphyrins and Phthalocyanines, 2020, vol. 24, no 01n03, p. 340-349.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.worldscientific.com/doi/abs/10.1142/S1088424619501128Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Synthesis and characterization of nickel(II) meso-tetraarylporphyrins fused to imidazolium rings across β,β-pyrrolic positions and X-ray structure of the porphyrin where two opposed pyrrole units are fused to an ... [+]
Synthesis and characterization of nickel(II) meso-tetraarylporphyrins fused to imidazolium rings across β,β-pyrrolic positions and X-ray structure of the porphyrin where two opposed pyrrole units are fused to an imidazolium ring are presented. The interactions between these mono-, bis-, tris- and tetrakis(imidazolium) porphyrins with human telomeric DNA G-quadruplexes (G4) were investigated using UV-vis absorption spectroscopy, Circular Dichroism (CD) spectroscopy and Fluorescence Resonance Energy Transfer (FRET) melting assay. Possible binding modes between cationic porphyrins and a selected G4 sequence (d[AG3(T2AG3)3]), and relative stabilities of porphyrin/G4 complexes are discussed. Excepting porphyrins fused to one imidazolium ring, the other derivatives interact with G4 structures and their stabilization strongly depends on the porphyrin structure (number and localization of the imidazolium rings). [-]
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