Design of metalloporphyrins fused to imidazolium rings for binding DNA G-quadruplexes
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Other documents of the author: Caporaletti, Francesca; RUBIO-MAGNIETO, JENIFER; Lo, Mamadou; Longevial, Jean-François; Rose, Clémence; Clément, Sébastien; van der Lee, Arie; Surin, Mathieu; Richeter, Sébastien
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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https://doi.org/10.1142/S1088424619501128 |
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Title
Design of metalloporphyrins fused to imidazolium rings for binding DNA G-quadruplexesAuthor (s)
Date
2020-01Publisher
World ScientificBibliographic citation
CAPORALETTI, Francesca, et al. Design of metalloporphyrins fused to imidazolium rings for binding DNA G-quadruplexes. Journal of Porphyrins and Phthalocyanines, 2020, vol. 24, no 01n03, p. 340-349.Type
info:eu-repo/semantics/articlePublisher version
https://www.worldscientific.com/doi/abs/10.1142/S1088424619501128Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Synthesis and characterization of nickel(II) meso-tetraarylporphyrins fused to imidazolium rings across β,β-pyrrolic positions and X-ray structure of the porphyrin where two opposed pyrrole units are fused to an ... [+]
Synthesis and characterization of nickel(II) meso-tetraarylporphyrins fused to imidazolium rings across β,β-pyrrolic positions and X-ray structure of the porphyrin where two opposed pyrrole units are fused to an imidazolium ring are presented. The interactions between these mono-, bis-, tris- and tetrakis(imidazolium) porphyrins with human telomeric DNA G-quadruplexes (G4) were investigated using UV-vis absorption spectroscopy, Circular Dichroism (CD) spectroscopy and Fluorescence Resonance Energy Transfer (FRET) melting assay. Possible binding modes between cationic porphyrins and a selected G4 sequence (d[AG3(T2AG3)3]), and relative stabilities of porphyrin/G4 complexes are discussed. Excepting porphyrins fused to one imidazolium ring, the other derivatives interact with G4 structures and their stabilization strongly depends on the porphyrin structure (number and localization of the imidazolium rings). [-]
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