Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction
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Other documents of the author: Yang, Jen-Hau; Presby, Rose; Jarvie, Adam A.; Rotolo, Renee; Fitch, R. Holly; Correa, Merce; Salamone, John
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https://doi.org/10.1007/s00213-019-05343-8 |
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Title
Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restrictionAuthor (s)
Date
2020Publisher
Springer VerlagISSN
0033-3158; 1432-2072Bibliographic citation
Yang, J., Presby, R.E., Jarvie, A.A. et al. Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction. Psychopharmacology 237, 33–43 (2020). https://doi.org/10.1007/s00213-019-05343-8Type
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007/s00213-019-05343-8Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Rationale Effort-based decision-making tasks offer animals choices between preferred reinforcers that require high effort to
obtain vs. low effort/low reward options. The neural mechanisms of effort-based choice are ... [+]
Rationale Effort-based decision-making tasks offer animals choices between preferred reinforcers that require high effort to
obtain vs. low effort/low reward options. The neural mechanisms of effort-based choice are widely studied in rats, and evidence
indicates that mesolimbic dopamine (DA) and related neural systems play a key role. Fewer studies of effort-based choice have
been performed in mice.
Objectives The present studies used touchscreen operant procedures (Bussey-Saksida boxes) to assess effort-based choice in
mice.
Methods CD1 mice were assessed on a concurrent fixed ratio 1 panel pressing/choice procedure. Mice were allowed to choose
between rearing to press an elevated panel on the touchscreen for a preferred food (strawberry milkshake) vs. consuming a
concurrently available less preferred alternative (high carbohydrate pellets).
Results The DA D2 antagonist haloperidol (0.05–0.15 mg/kg IP) produced a dose-related decrease in panel pressing. Intake of
food pellets was not reduced by haloperidol, and in fact, there was a significant quadratic trend, indicating a tendency for pellet
intake to increase at low/moderate doses. In contrast, reinforcer devaluation by removing food restriction substantially decreased
both panel pressing and pellet intake. In free-feeding choice tests, mice strongly preferred milkshake vs. pellets. Haloperidol did
not affect food intake or preference.
Conclusion Haloperidol reduced the tendency to work for food, but this reduction was not due to decreases in primary food
motivation or preference. Mouse touchscreen procedures demonstrate effects of haloperidol that are similar but not identical to
those shown in rats. These rodent studies may be relevant for understanding motivational dysfunctions in humans. [-]
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Psychopharmacology (2020) 237:33–43Investigation project
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