Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
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Other documents of the author: Costumero, Víctor; d'Oleire Uquillas, Federico; Diez, Ibai; Andorrà, Magi; Basaia, Silvia; Bueichekú, Elisenda; Ortiz-Terán, Laura; Belloch, Vicente; Escudero, Joaquín; Avila, Cesar; Sepulcre, Jorge
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Distance disintegration delineates the brain connectivity failure of Alzheimer's diseaseAuthor (s)
Date
2019-12-14Publisher
ElsevierISSN
0197-4580; 1558-1497Bibliographic citation
COSTUMERO, Víctor, et al. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiology of Aging, 2020, vol. 88, p. 51-60.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0197458019304336Version
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Alzheimer's disease (AD) is associated with brain network dysfunction. Network-based investigations of brain connectivity have mainly focused on alterations in the strength of connectivity; however, the network breakdown ... [+]
Alzheimer's disease (AD) is associated with brain network dysfunction. Network-based investigations of brain connectivity have mainly focused on alterations in the strength of connectivity; however, the network breakdown in AD spectrum is a complex scenario in which multiple pathways of connectivity are affected. To integrate connectivity changes that occur under AD-related conditions, here we developed a novel metric that computes the connectivity distance between cortical regions at the voxel level (or nodes). We studied 114 individuals with mild cognitive impairment, 24 with AD, and 27 healthy controls. Results showed that areas of the default mode network, salience network, and frontoparietal network display a remarkable network separation, or greater connectivity distances, from the rest of the brain. Furthermore, this greater connectivity distance was associated with lower global cognition. Overall, the investigation of AD-related changes in paths and distances of connectivity provides a novel framework for characterizing subjects with cognitive impairment; a framework that integrates the overall network topology changes of the brain and avoids biases toward unreferenced connectivity effects. [-]
Is part of
Neurobiology of Aging, Volume 88, April 2020.Investigation project
No. R01AG061445 and R01AG061811, K23-EB019023 to J. SepulcreRights
© 2019 Elsevier Inc. All rights reserved. Licencia CC-BY-NC-ND
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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