Inflammation, atrophy and gastric cancer
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/12
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BIBLIOMetadatos
Título
Inflammation, atrophy and gastric cancerDOI
10.1172/JCI30111Fecha de Publicación
2007-01Resumen
The association between chronic inflammation and cancer is now well established. This association has recently received renewed interest with the recognition that microbial pathogens can be responsible for the chronic ... [+]
The association between chronic inflammation and cancer is now well established. This association has recently received renewed interest with the recognition that microbial pathogens can be responsible for the chronic inflammation observed in many cancers, particularly those originating in the gastrointestinal system. A prime example is Helicobacter pylori, which infects 50% of the world’s population and is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia, and gastric cancer. This Review provides an overview of recent progress in elucidating the bacterial properties responsible for colonization of the stomach, persistence in the stomach, and triggering of inflammation, as well as the host factors that have a role in determining whether gastritis progresses to gastric cancer. We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment. [-]
Publicado en
J Clin Invest. 2007 Jan 2; 117(1): 60–69.Tipo de documento
info:eu-repo/semantics/articleEditor
Rexford S. Ahima (American Society for Clinical Investigation)Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess