Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness
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Otros documentos de la autoría: Gil-Cosano, Jose J.; Gracia-Marco, Luis; Ubago-Guisado, Esther; LABAYEN , IDOIA; Adelantado-Renau, Mireia; Cadenas-Sanchez, Cristina; Mora González, José; Plaza Florido, Abel Adrian; Aguilera, Concepción M.; Gómez Vida, José; Maldonado, José; Jürimäe, Jaak; Ortega, Francisco B
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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INVESTIGACIONMetadatos
Título
Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitnessAutoría
Fecha de publicación
2020Editor
Springer NatureISSN
0031-3998; 1530-0447Cita bibliográfica
Gil-Cosano, J.J., Gracia-Marco, L., Ubago-Guisado, E. et al. Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness. Pediatr Res 87, 42–47 (2020). https://doi.org/10.1038/s41390-019-0572-8Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.nature.com/articles/s41390-019-0572-8Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Objectives
To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.
Methods
Plasma interleukin-1β ... [+]
Objectives
To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.
Methods
Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8–11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry.
Results
IL-6 (β = −0.136) and VEGF (β = −0.099) were associated with TBLH BMC, while TNF-α (β = −0.345) and IL-1β (β = 0.212) were associated with LS BMC (P < 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = −0.152) and TNF-α with LS BMC (β = −0.491) in the low-fitness group, while no association was found in the high-fitness group.
Conclusion
IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass. [-]
Publicado en
Pediatric Research volume 87, pages42–47(2020)Proyecto de investigación
BES-2014-068829, SOMM17/6107/UGR, I 2017-2021, RD16/0022, PREDOC/2015/13, FPU 16/02760, PI-0002-2017Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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