High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohort study.
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Other documents of the author: Navarrete-Muñoz, Eva María; Valera-Gran, Desirée; Garcia de la Hera, Manuela; González-Palacios, Sandra; Riaño-Galan, Isolina; Murcia, Mario; Lertxundi, Aitana; Guxens, Mònica; Tardon, Adonina; Amiano, Pilar; Vrijheid, Martine; Rebagliato, Marisa; Vioque, Jesus
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https://doi.org/10.1007/s00394-017-1588-7 |
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Title
High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohort study.Author (s)
Date
2019Publisher
SpringerBibliographic citation
NAVARRETE-MUÑOZ, Eva María;VALERA-GRAN,Desirée; GARCÍA DE LA HERA, Manuela; GONZÁLEZ-PALACIOS, Sandra; RIAÑO-GALAN, Isolina; MURCIA, Mario; LERTXUNDI, Aitana; GUXENS, Mònica; TARDON, Adonina; AMIANO, Pilar; VRIJHEID, Martine; REBAGLIATO, Marisa; VIOQUE, Jesús (2018). High doses of folic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohort study. European Journal of Nutrition, v. 58, p. 241-251Type
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/article/10.1007%2Fs00394-017-1588-7Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Purpose We investigated the association between maternal use of folic acid (FA) during pregnancy and child anthropometric
measures at birth.
Methods We included 2302 mother–child pairs from a population-based birth ... [+]
Purpose We investigated the association between maternal use of folic acid (FA) during pregnancy and child anthropometric
measures at birth.
Methods We included 2302 mother–child pairs from a population-based birth cohort in Spain (INMA Project). FA dosages
at first and third trimester of pregnancy were assessed using a specific battery questionnaire and were categorized in non-user,
<1000, 1000–4999, and ≥5000 µg/day. Anthropometric measures at birth (weight in grams, length and head circumference
in centimetres) were obtained from medical records. Small for gestational age according to weight (SGA-w), length (SGA-l)
and head circumference (SGA-hc) were defined using the 10th percentile based on Spanish standardized growth reference
charts. Multiple linear and logistic regression analyses were used to explore the association between FA dosages in different
stages of pregnancy and child anthropometric measures at birth.
Results In the multiple linear regression analysis, we found a tendency for a negative association between the use of high
dosages of FA (≥5000 µg/day) in the periconceptional period of pregnancy and weight at birth compared to mothers who
were non-users of FA (β = − 73.83; 95% CI − 151.71, 4.06). In the multiple logistic regression, a greater risk of SGA-w was
also evident among children whose mothers took FA dosages of 1000–4999 (OR=2.21; 95% CI 1.17, 4.19) and of ≥5000 µg/
day (OR=2.32; 95% CI 1.06, 5.08) compared to mothers non-users of FA in the periconceptional period of pregnancy.
Conclusion Our findings suggest that a high dosage of FA (≥1000 µg/day) may be associated with an increased risk of
SGA-w at birth. [-]
Is part of
European Journal of Nutrition (2019), v. 58Investigation project
1) Instituto de Salud Carlos III and Spanish Ministry of Health (Red INMA G03/176; CB06/02/0041; FIS 97/0588; 00/0021-2, PI061756; PS0901958; FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314; 09/02647; FIS-PI041436, FIS-PI081151, FISPI06/0867; FIS-PS09/00090, FIS-PI042018, FIS-PI09 02311, FIS PI11/01007, FISPI13/02429) ; 2) Generalitat de Catalunya-CIRIT 1999SGR 00241; 3) Department of Health of the Basque Government (2005111093 and 2009111069); 4) Provincial Government of Guipuzcoa (DFG06/004 and DFG08/001).Rights
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