Liposome-Enveloped Molecular Nanogels
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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http://dx.doi.org/10.1021/acs.langmuir.9b02282 |
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Title
Liposome-Enveloped Molecular NanogelsDate
2019Publisher
American Chemical SocietyISSN
0743-7463; 1520-5827Bibliographic citation
TORRES-MARTÍNEZ, Ana, et al. Liposome-enveloped molecular nanogels. Langmuir, 2019, vol. 35, no 41, p. 13375-13381.Type
info:eu-repo/semantics/articlePublisher version
https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.9b02282Version
info:eu-repo/semantics/publishedVersionAbstract
Novel hydrogel@liposome particles were prepared by pHtriggered molecular gel formation inside of liposomes loaded with a lowmolecular weight gelator derived from L-valine (1). Liposome formation was
carried out using ... [+]
Novel hydrogel@liposome particles were prepared by pHtriggered molecular gel formation inside of liposomes loaded with a lowmolecular weight gelator derived from L-valine (1). Liposome formation was
carried out using L-α-phosphatidylcholine (PC) and cholesterol as
components of the lipid bilayer. Molecular hydrogelator 1 and pyranine, a
ratiometric fluorescent pH probe, were entrapped in the liposomes at pH 9
and posterior acidification with D-glucono-1,5-lactone to pH 5−6 provoked
intraliposomal gel formation. Removal of the lipid bilayer with sodium
dodecyl sulfate yielded naked nanogel particles. The systems were characterized by transmission electron microscopy and
dynamic light scattering. The hydrogel@liposomes were loaded with doxorubicin, showing a similar release than that observed
for liposomes. The hybrid particles described here are the first case of nonpolymeric hydrogel@liposome systems reported. This
type of nanocarriers merges the benefits of liposomal vehicles with the inherent stimuli responsiveness and enhanced
biocompatibility of hydrogels formed by low-molecular weight molecules, foretelling a potential use in environmentally sensitive
drug release. [-]
Is part of
Langmuir 2019, 35.Investigation project
CTQ2015-71004-R ; UJIB2018-54 ; FPU14/05974 ;Rights
© 2019 American Chemical Societ
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