Chromatographic determination of antiparasitic drugs in plasma samples for the treatment of STH infections
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Title
Chromatographic determination of antiparasitic drugs in plasma samples for the treatment of STH infectionsAuthor (s)
Tutor/Supervisor; University.Department
Esteve Romero, Josep Salvador; Universitat Jaume I. Departament de Química Física i AnalíticaDate
2019-10Publisher
Universitat Jaume IAbstract
The main objective of this final degree work was to develop a new simple, fast,
selective and reliable analytical method for the determination of two antiparasitic drugs,
using micellar liquid chromatography (MLC) ... [+]
The main objective of this final degree work was to develop a new simple, fast,
selective and reliable analytical method for the determination of two antiparasitic drugs,
using micellar liquid chromatography (MLC) with absorbance detection. This technique
was chosen because it allows the direct injection of biological samples without any
previous treatment. This fact is an advantage over other analytical techniques reviewed
in the literature, which are more expensive and require more longer and complex
experimental procedures. Another important advantage is the use of mobile phases of
high water content in isocratic mode, compared to the conventional RP-HPLC that uses
hydro-organic mobile phases circulating in gradient. This fact results in less time for
analysis and less use of toxic organic solvents. [-]
Description
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2018/2019
Type
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This item appears in the folowing collection(s)
- Grau en Química [265]