Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment
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Altres documents de l'autoria: Vendrell Criado, Victoria; Angulo-Pachón, César A.; Miravet, Juan; Galindo, Francisco; Miranda, Miguel A.; Jiménez, M. Consuelo
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INVESTIGACIONMetadades
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Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environmentAutoria
Data de publicació
2019-11-06Editor
ElsevierCita bibliogràfica
VENDRELL-CRIADO, Victoria, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. Journal of Photochemistry and Photobiology B: Biology, 2020, 202: 111686.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.sciencedirect.com/science/article/pii/S1011134419312448#!Versió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
In this work, a molecular hydrogel made of gelator (S)-4-((3-methyl-1-(nonylamino)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid (SVN) has been employed as soft container to modify the photochemical and photophysical ... [+]
In this work, a molecular hydrogel made of gelator (S)-4-((3-methyl-1-(nonylamino)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid (SVN) has been employed as soft container to modify the photochemical and photophysical behavior of the antipsychotic drug cyamemazine (CMZ). The interaction of CMZ with the gel network has been evidenced by fluorescence spectroscopy through a hypsochromic shift of the emission band (from λmax = 521 nm in solution to λmax = 511 nm in the gel) and an increase of the fluorescence lifetime (5.6 ns in PBS vs. 7.2 ns in the gel). In the laser flash photolysis experiments on CMZ/SVN systems, the CMZ triplet excited state (3CMZ*), monitored at λ = 320 nm, has been more efficiently generated and became much longer-lived than in solution (2.7 μs vs. 0.7 μs); besides, photochemical ionization leading to the radical cation CMZ+• was disfavored. In the steady-state experiments, photooxidation of CMZ to afford the N,S-dioxide derivative CMZ-SONO has been retarded in the gel, which provides a more lipophilic and constrained microenvironment. Both the photophysical properties and the photoreactivity are in agreement with CMZ located in a less polar domain when entrapped in the supramolecular gel, as result of the interaction of the drug with the fibers of the supramolecular SVN gel. [-]
Proyecto de investigación
Spanish Government (CTQ2016-78875-P and CTQ2015-71004-R) ; Generalitat Valenciana (PROMETEO/2017/075)Drets d'accés
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