Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease
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Otros documentos de la autoría: Espinosa-Fernández, Verónica; Mañas-Ojeda, Aroa; Pacheco-Herrero, Mar; Castro-Salazar, Ernestina; Ros Bernal, Francisco; Sánchez-Pérez, Ana María
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Título
Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s diseaseAutoría
Fecha de publicación
2019-11-18Editor
ElsevierISSN
0166-4328; 1872-7549Cita bibliográfica
ESPINOSA-FERNÁNDEZ, Verónica, et al. Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´ s disease. Behavioural brain research, 2019, vol. 374, p. 112106.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0166432819309246#!Versión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Neuroinflammation and insulin resistance in the brain are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Even though traditionally Alzheimer´s disease has been associated to Aβ deposits ... [+]
Neuroinflammation and insulin resistance in the brain are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Even though traditionally Alzheimer´s disease has been associated to Aβ deposits and hyperphosphorylated Tau intracellular tangles, several studies show that neuroinflammation may be the initial cause that triggers degeneration. Accordingly, a number of natural supplements that improves brain insulin sensitivity and reduce neuroinflammation have been proposed as good choices in the therapeutic prevention of cognitive decline. Further supporting this evidence, we show that phytohormone Abscisic Acid, can prevent memory impairment and neuroinflammation markers in a triple transgenic mouse model, where no peripheral inflammatory changes have occurred. Moreover, our data strongly suggests that early intervention is critical for good prognosis, and that cognitive improvement requires longer treatment than recovering neuroinflammation markers. [-]
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Behavioural brain research, 2019, vol. 374Derechos de acceso
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