Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
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Otros documentos de la autoría: Martínez-Rodríguez, Elena; Martín Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Martinez-Garcia, Fernando; Nacher, Juan; Lanuza, Enrique; Santos, Mónica; Agustín-Pavón, Carmen
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INVESTIGACIONMetadatos
Título
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory systemAutoría
Fecha de publicación
2019-05Editor
SpringerISSN
1863-2653; 1863-2661Cita bibliográfica
MARTÍNEZ-RODRÍGUEZ, Elena, et al. Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system. Brain Structure and Function, 2019, vol. 224, no 4, p. 1647-1658Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://link.springer.com/article/10.1007/s00429-019-01860-6Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
The protein doublecortin is mainly expressed in migrating neuroblasts and immature neurons. The X-linked gene MECP2, associated to several neurodevelopmental disorders such as Rett syndrome, encodes the protein ... [+]
The protein doublecortin is mainly expressed in migrating neuroblasts and immature neurons. The X-linked gene MECP2, associated to several neurodevelopmental disorders such as Rett syndrome, encodes the protein methyl-CpG-binding protein 2 (MeCP2), a regulatory protein that has been implicated in neuronal maturation and refinement of olfactory circuits. Here, we explored doublecortin immunoreactivity in the brain of young adult female Mecp2-heterozygous and male Mecp2-null mice and their wild-type littermates. The distribution of doublecortin-immunoreactive somata in neurogenic brain regions was consistent with previous reports in rodents, and no qualitative differences were found between genotypes or sexes. Quantitatively, we found a significant increase in doublecortin cell density in the piriform cortex of Mecp2-null males as compared to WT littermates. A similar increase was seen in a newly identified population of doublecortin cells in the olfactory tubercle. In these olfactory structures, however, the percentage of doublecortin immature neurons that also expressed NeuN was not different between genotypes. By contrast, we found no significant differences between genotypes in doublecortin immunoreactivity in the olfactory bulbs. Nonetheless, in the periglomerular layer of Mecp2-null males, we observed a specific decrease of immature neurons co-expressing doublecortin and NeuN. Overall, no differences were evident between Mecp2-heterozygous and WT females. In addition, no differences could be detected between genotypes in the density of doublecortin-immunoreactive cells in the hippocampus or striatum of either males or females. Our results suggest that MeCP2 is involved in neuronal maturation in a region-dependent manner. [-]
Descripción
This is a pre-print of an article published in Brain Structure and Function. The final authenticated version is available online at: https://doi.org/10.1007/s00429-019-01860-6
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Brain Structure and Function, 2019, vol. 224, no 4Derechos de acceso
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info:eu-repo/semantics/openAccess
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