The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults
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Altres documents de l'autoria: Martinez Tellez, Borja; Adelantado-Renau, Mireia; Acosta, Francisco M.; Sanchez-Delgado, Guillermo; Martinez Nicolas, Antonio; Boon, Mariëtte; Llamas-Elvira, Jose Manuel; Martínez‐Vizcaíno, Vicente; Ruiz, Jonatan R.
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/174799
comunitat-uji-handle3:10234/174800
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INVESTIGACIONMetadades
Títol
The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18F-Fluorodeoxyglucose in the Thermoregulatory System in Young AdultsAutoria
Data de publicació
2019Editor
WileyISSN
1930-7381; 1930-739XCita bibliogràfica
MARTINEZ‐TELLEZ, Borja, et al. The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults. Obesity, 2019, vol. 27, no 6, p. 963-970.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://onlinelibrary.wiley.com/doi/10.1002/oby.22461Versió
info:eu-repo/semantics/submittedVersionResum
Objective: This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist ... [+]
Objective: This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal-ET and WT (as a proxy of peripheral vasoconstriction/vasodilation).Methods: The levels of BAT were quantified by cold-induced 18F-fluorodeoxyglucose–positron emission tomography/computed tomography scan and measured the Personal-ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74.6% women).Results: The study found that BAT volume and metabolic activity played a positive and significant role (up to 25.4%) in the association between Personal-ET and WT. In addition, at the coldest temperatures, the participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle activity.Conclusions: BAT volume and metabolic activity play a role in the relationship between Personal-ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat. [-]
Publicat a
Obesity (2019) 27, 963-970. doi:10.1002/oby.22461Proyecto de investigación
PI13/01393 ; DEP2016-79512-R ; FPU 13/04365 ; Red SAMID RD16/0022 ; SOMM17/6107/UGR ; PREDOC/2015/13 ; CB16/10/00239 ; 19899/GERM/15Drets d'accés
"This is the pre-peer reviewed version of the following article: MARTINEZ‐TELLEZ, Borja, et al. The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18F‐Fluorodeoxyglucose in the Thermoregulatory System in Young Adults. Obesity, 2019, vol. 27, no 6, p. 963-970., which has been published in final form at https://doi.org/10.1002/oby.22461. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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