The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample
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Other documents of the author: Soler, Jordi; Arias, Barbara; Moya, Jorge; Ibáñez, Manuel I; Ortet, Generós; Fañanás Saura, Lourdes; Fatjó-Vilas, Mar
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Title
The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sampleAuthor (s)
Date
2019Publisher
ElsevierBibliographic citation
SOLER, Jordi, et al. The interaction between the ZNF804A gene and cannabis use on the risk of psychosis in a non-clinical sample. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, vol. 89, p. 174-180.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0278584618300988Version
info:eu-repo/semantics/submittedVersionSubject
Abstract
The ZNF804A gene and cannabis use are risk factors for psychosis and both have also been associated with
schizotypal traits. This study aimed to investigate: i) the association of lifetime cannabis use (and its dose ... [+]
The ZNF804A gene and cannabis use are risk factors for psychosis and both have also been associated with
schizotypal traits. This study aimed to investigate: i) the association of lifetime cannabis use (and its dose effect)
with schizotypal personality traits, and ii) whether the genetic variability at ZNF804A gene modulates that
association.
Our sample consisted of 385 Spanish non-clinical subjects (43.1% males, mean age = 21.11(2.19)).
Schizotypy was evaluated using the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B):
Cognitive-Perceptual (SPQ-CP), Interpersonal (SPQ-I) and Disorganized (SPQ-D). Subjects were classified according to their frequency of cannabis consumption, and dichotomized as users or non-users. The effects of a
genetic variant of ZNF804A (rs1344706) and cannabis use, as well as their interaction, on each of the three SPQB factors were assessed using linear models and permutation tests. Sex, SCL anxiety scores and use of other drugs
were included as covariates.
Our analysis showed a significant relationship between ZNF804A and SPQ-I: AA genotype was associated with
higher scores (β = 0.885 pFDR = .018). An interaction between the AA genotype and lifetime cannabis use was
found in SPQ-CP (β = 1.297 pFDR = 0.018). This interaction showed a dose–effect pattern among AA subjects:
schizotypy scores increased with increasing frequency of cannabis use (sporadic users: β = 0.746 pFDR = 0.208;
monthly users: β = 1.688 pFDR = 0.091; intense users: β = 1.623 pFDR = 0.038).
These results add evidence on that the ZNF804A gene is associated with schizotypy and suggest that the
interaction between cannabis use and ZNF804A genotype could modulate psychosis proneness. [-]
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Progress in Neuropsychopharmacology & Biological Psychiatry, 89 (2019)Rights
0278-5846/ © 2018 Published by Elsevier Inc.
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