Photomodulation of DNA‐Templated Supramolecular Assemblies
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Other documents of the author: RUBIO-MAGNIETO, JENIFER; Phan, Tuan‐Anh; Fossépré, Mathieu; Matot, Valérie; Knoops, Jérémie; Jarrosson, Thibaut; Dumy, Pascal; Serein‐Spirau, Françoise; Niebel, Claude; Ulrich, Sébastien; Surin, Mathieu
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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https://doi.org/10.1002/chem.201704538 |
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Title
Photomodulation of DNA‐Templated Supramolecular AssembliesAuthor (s)
Date
2018-01-12Publisher
WileyISSN
0947-6539; 1521-3765Bibliographic citation
RUBIO‐MAGNIETO, Jenifer, et al. Photomodulation of DNA‐templated supramolecular assemblies. Chemistry–A European Journal, 2018, vol. 24, no 3, p. 706-714Type
info:eu-repo/semantics/articlePublisher version
https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201704538Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
A new type of DNA ligand that contains a phosphate‐binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double‐s ... [+]
A new type of DNA ligand that contains a phosphate‐binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double‐stranded DNA, whereas it partially desorbs upon trans–cis isomerisation with light. The ability to photoswitch the ligand upon interaction with DNA is evidenced by (chir)optical signatures, and deciphered by the differences of binding geometry, stability, and dynamics of the DNA/ligand complexes for the two isomers. We exploit these properties to photomodulate DNA‐templated self‐assembly, through the incorporation of another π‐stacking DNA ligand, which together with the photoresponsive ligand form mixed supramolecular complexes along DNA. Our study demonstrates that well‐designed photoresponsive DNA binders can be used to modulate multicomponent supramolecular DNA assemblies. [-]
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Chemistry–A European Journal, 2018, vol. 24, no 3Investigation project
Fonds de la Recherche Scientifique-FNRS: 1.B333.15F, F.4532.16; Science Policy Office of the Belgian Federal Government: BELSPO-PAI 7/5; LabEx CheMISyst: ANR-10-LABX-05-01Rights
Copyright © John Wiley & Sons, Inc.
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