Dopamine antagonists reduce selection of reinforcers that require vikgor: correlation with DARPP32
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Title
Dopamine antagonists reduce selection of reinforcers that require vikgor: correlation with DARPP32Author (s)
Tutor/Supervisor; University.Department
Correa Sanz, Mercè; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i PsicobiologiaDate
2018-09-11Publisher
Universitat Jaume IAbstract
Introduction: Dopamine (DA) is a neurotransmitter that is involved in vigor, persistence and work
output in normal motivation. In fact, nucleus accumbens (Nacb) DA is a critical component of
the neural circuitry ... [+]
Introduction: Dopamine (DA) is a neurotransmitter that is involved in vigor, persistence and work
output in normal motivation. In fact, nucleus accumbens (Nacb) DA is a critical component of
the neural circuitry that regulates behavioral activation, and effort-based decision-making. An
imbalance of this system produces several motivational symptoms such as anergia or fatigue, seen
in pathologies like depression. In animal models, DA receptor antagonists reallocate instrumental
behavior away from tasks that require high levels of activation to low-effort tasks.
Objective: We evaluate the impact of DA receptor antagonism (D1, D2 and D3 receptors) on
performance of a decision-making task for the assessment of reinforcer preferences; the T-maze
RW-sucrose pellets-odor choice task. We also assessed the impact on preferences of changing the
value of the reinforcers.
Methods: CD1 male mice received Ecopipam, a D1 receptor antagonist (ECO, 0.2 mg/kg),
Raclopride, a D2 receptor antagonist (RACLO, 0.75 mg/kg), or SB277011A, a D3 receptor
antagonist (SB, 1.5 mg/kg) and were assessed in the T-maze. DA receptor-activity-related
markers (pDARPP32-Thr75 and Thr34) in Nacb were assessed using immunoblotting.
Results: All DA antagonists decreased time running but only ECO and SB increased time eating.
These behavioral effects were parallel to pDARPP-32(Thr34) changes. Also, the bright light over
the RW, increasing resistance in the RW, and using social odors reduced time spent running, but
the pattern of effects was very different to the pattern observed for DA antagonists.
Conclusions: This pilot study suggest that DA receptor antagonists could induce a shift towards
more sedentary sources of reinforcement that is paralleled by pDARPP-32(Thr34) changes. [-]
Subject
Description
Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2017/2018
Type
info:eu-repo/semantics/masterThesisRights
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